| Identification | Back Directory | [Name]
2,4-Undecadienoic acid, 11-[(2R,3R)-3-(hydroxymethyl)-4-oxo-2-oxetanyl]-3,5,7-trimethyl-, methyl ester, (2E,4E,7R)- | [CAS]
112965-15-8 | [Synonyms]
2,4-Undecadienoic acid, 11-[(2R,3R)-3-(hydroxymethyl)-4-oxo-2-oxetanyl]-3,5,7-trimethyl-, methyl ester, (2E,4E,7R)- | [Molecular Formula]
C19H30O5 | [MOL File]
112965-15-8.mol | [Molecular Weight]
338.44 |
| Hazard Information | Back Directory | [Description]
L 668411 is the 2,3-ditritiated methyl ester of L 659699; inhibits HMG-CoA synthase. | [Uses]
L 668411 is a β-lactone inhibitor with activity against 3-hydroxy-3-methylglutaryl-CoA synthase and cholesterol biosynthesis. L 668411 inhibits rat liver cytosolic 3-hydroxy-3-methylglutaryl-CoA synthase and [14C] acetate incorporation into sterols in cultured Hep G2 cells, and the inhibition appears to be irreversible in cells but reversible in cultured cells and animals. | [References]
[1] Inhibition of 3-hydroxy-3-methylglutaryl-CoA synthase and cholesterol biosynthesis by beta-lactone inhibitors and binding of these inhibitors to the enzyme DOI:10.1042/bj2890889 |
|
|