| Identification | Back Directory | [Name]
demoxytocin | [CAS]
113-78-0 | [Synonyms]
demoxytocin
Deaminoxytocin
deaminooxytocin
Demossitocina [DCIT]
demoxytocin USP/EP/BP
(Deamino-Cys1)-Oxytocin
1-(3-Mercaptopropionic acid)oxytocin
Glycinamide, N-(3-mercapto-1-oxopropyl)-L-tyrosyl-L-isoleucyl-L-glutaminyl-L-asparaginyl-L-cysteinyl-L-prolyl-L-leucyl-, cyclic (1→5)-disulfide
1-[4-(2-amino-2-keto-ethyl)-7-(3-amino-3-keto-propyl)-13-(4-hydroxybenzyl)-3,6,9,12,15-pentaketo-10-sec-butyl-18,19-dithia-2,5,8,11,14-pentazacycloicosane-1-carbonyl]-N-[1-[(2-amino-2-keto-ethyl)carbamoyl]-3-methyl-butyl]pyrrolidine-2-carboxamide
N-[1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]-1-[4-(2-amino-2-oxoethyl)-7-(3-amino-3-oxopropyl)-10-butan-2-yl-13-[(4-hydroxyphenyl)methyl]-3,6,9,12,15-pentaoxo-18,19-dithia-2,5,8,11,14-pentazacycloicosane-1-carbonyl]pyrrolidine-2-carboxamide
N-[1-[(2-azanyl-2-oxo-ethyl)amino]-4-methyl-1-oxo-pentan-2-yl]-1-[[4-(2-azanyl-2-oxo-ethyl)-7-(3-azanyl-3-oxo-propyl)-10-butan-2-yl-13-[(4-hydroxyphenyl)methyl]-3,6,9,12,15-pentaoxo-18,19-dithia-2,5,8,11,14-pentazacycloicos-1-yl]carbonyl]pyrrolidine-2-carboxamide | [EINECS(EC#)]
204-034-9 | [Molecular Formula]
C43H65N11O12S2 | [MDL Number]
MFCD00867797 | [MOL File]
113-78-0.mol | [Molecular Weight]
992.17 |
| Chemical Properties | Back Directory | [Boiling point ]
1518.8±65.0 °C(Predicted) | [density ]
1.263±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
9.90±0.15(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Demoxytocin, a heterodetic cyclic peptide, is an analog of oxytocin. Demoxytocin affects the permeability of the cell membrane, increasing the content of calcium ions in smooth muscle cells, increasing its contraction. Demoxytocin also stimulates the contraction of smooth muscles of the uterus. Demoxytocin has the function of oxytocin. Demoxytocin can be used to research stimulation of labor in cases of premature rupture[1]. | [Definition]
ChEBI: Demoxytocin is a heterodetic cyclic peptide that is the synthetic analog of the peptide hormone oxytocin where the free amino group in the half-cystine residue is replaced by hydrogen. The mechanism of action and pharmacological properties of demoxytocin and oxytocin are similar. The drug affects the permeability of the cell membrane, increasing the content of calcium ions in smooth muscle cells, thereby increasing its contraction. It stimulates the contraction of smooth muscles of the uterus, as well as stimulating the contraction of myoepithelial cells of the mammary gland, and enhances the secretion of milk. It has a role as an oxytocic. It is functionally related to an oxytocin. | [References]
[1] Westergaard JG, et al. Use of oral oxytocics for stimulation of labor in cases of premature rupture of the membranes at term. A randomized comparative study of prostaglandin E2 tablets and demoxytocin resoriblets. Acta Obstet Gynecol Scand. 1983;62(2):111-6. DOI:10.3109/00016348309155773 |
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