| Identification | Back Directory | [Name]
3-Deoxysappanone B | [CAS]
113122-54-6 | [Synonyms]
3-Deoxysappanone
3-Deoxysappanone B
3-deoxyhematoxylin B
4H-1-Benzopyran-4-one, 3-[(3,4-dihydroxyphenyl)methyl]-2,3-dihydro-7-hydroxy-, (R)-
4H-1-Benzopyran-4-one, 3-[(3,4-dihydroxyphenyl)methyl]-2,3-dihydro-7-hydroxy-, (3R)- | [Molecular Formula]
C16H14O5 | [MOL File]
113122-54-6.mol | [Molecular Weight]
286.28 |
| Hazard Information | Back Directory | [Uses]
Deoxysappanone B (3-Deoxysappanone B) is a homoisoflavone compound isolated from Caesalpinia sappan L (Lignum Sappan). Deoxysappanone B has anti-neuroinflammatory and neuroprotective effects and inhibits the production of neuroinflammatory mediators by blocking the IκB kinase (IKK)-NF-κB and p38/ERK MAPK pathways. Deoxysappanone B can be used in disease studies of neuritis and inflammation-related neurological damage[1]. | [References]
[1] Ke-Wu Zeng, et al. Deoxysappanone B, a homoisoflavone from the Chinese medicinal plant Caesalpinia sappan L., protects neurons from microglia-mediated inflammatory injuries via inhibition of IκB kinase (IKK)-NF-κB and p38/ERK MAPK pathways. Eur J Pharmacol. 2015 Feb 5;748:18-29. DOI:10.1016/j.ejphar.2014.12.013 |
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