| Identification | Back Directory | [Name]
JMV 236 | [CAS]
113137-57-8 | [Synonyms]
t-Boc(nle(28
31))-cck (26-33)
t-Boc(nle(28,31))-cck (26-33)
Boc-Asp-Tyr(SO3-)-Nle-Gly-Trp-Nle-Asp-Phe-NH2
L-Phenylalaninamide, N-[(1,1-dimethylethoxy)carbonyl]-L-α-aspartyl-O-sulfo-L-tyrosyl-L-norleucylglycyl-L-tryptophyl-L-norleucyl-L-α-aspartyl- (9CI) | [Molecular Formula]
C56H74N10O18S | [MOL File]
113137-57-8.mol | [Molecular Weight]
1207.31 |
| Hazard Information | Back Directory | [Description]
Jmv 236 is a cholecystokinin antagonist. | [Uses]
JMV 236 is a cholecystokinin antagonist with appetite-suppressing activity. JMV 236 affects the regulation of food intake through the interaction of the intestinal endogenous peptide PrRP and the CCK1 receptor. The administration of JMV 236 activates PrRP neurons located in the NTS, thereby enhancing its appetite-suppressing effect. JMV 236 has significant effects on areas of the central nervous system associated with food intake, especially during states of starvation[1]. | [References]
[1] Cholecystokinin system is involved in the anorexigenic effect of peripherally applied palmitoylated prolactin-releasing peptide in fasted mice DOI:10.33549/physiolres.934694 |
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