| Identification | Back Directory | [Name]
2-AMINO-2-(3-(TRIFLUOROMETHYL)PHENYL)ACETIC ACID HYDROCHLORIDE | [CAS]
1134915-25-5 | [Synonyms]
2-(3-Trifluoromethylphenyl)glycine (hydrochloride)
AMINO[3-(TRIFLUOROMETHYL)PHENYL]ACETIC ACID HYDROCHLORIDE
2-amino-2-[3-(trifluoromethyl)phenyl]acetic acid,hydrochlor
2-AMINO-2-(3-(TRIFLUOROMETHYL)PHENYL)ACETIC ACID HYDROCHLORIDE
rel-(2R)-2-amino-2-[3-(trifluoromethyl)phenyl]acetic acid hydrochloride | [Molecular Formula]
C9H9ClF3NO2 | [MDL Number]
MFCD07371458 | [MOL File]
1134915-25-5.mol | [Molecular Weight]
255.62 |
| Hazard Information | Back Directory | [Uses]
2-(3-Trifluoromethylphenyl)glycine hydrochloride is a precursor of substituted 2-acetamido-5-aryl-l, 2,4-triazolones. Substituted 2-acetamido-5-aryl-l, 2,4-triazolones are dual V1a/V2 receptor antagonists and can be used in cardiovascular disease research[1]. | [Synthesis]
Example 95A: Synthesis of 2-amino-2-(3-trifluoromethylphenyl)acetic acid hydrochloride
1.00 g (3.13 mmol) of N-tert-butoxycarbonyl-2-(3-trifluoromethylphenyl)-DL-glycine was mixed with 15.7 mL of a dioxane solution of 4N HCl and stirred overnight at room temperature. Upon completion of the reaction, the volatile components were removed using a rotary evaporator. The residue was dried under high vacuum (HV) to give 795 mg (99% of theoretical yield) of 2-amino-2-(3-trifluoromethylphenyl)acetic acid hydrochloride.LC/MS [Method 2]: rt = 0.79 min; m/z = 220 (M + H)+. | [storage]
Store at -20°C | [References]
[1] Ulf Brüggemeier, et al. Substituted 2-acetamido-5-aryl-1,2,4-triazolones and use thereof. WO2010105770A1 |
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