| Identification | Back Directory | [Name]
CASPASE INHIBITOR I, BIOTIN CONJUGATE | [CAS]
1135688-15-1 | [Synonyms]
BIOTIN-VAD-FMK
BIOTIN-X-VAD-FMK
Biotin-VAD-FMK?, >98%
BIOTIN-VAL-ALA-ASP(OME)-FMK
CASPASE INHIBITOR I, BIOTIN CONJUGATE
BIOTIN-VAL-ALA-ASP(OME)-FLUOROMETHYLKETONE | [Molecular Formula]
C30H49FN6O8S | [MDL Number]
MFCD01322989 | [MOL File]
1135688-15-1.mol | [Molecular Weight]
672.81 |
| Chemical Properties | Back Directory | [Boiling point ]
1045.7±65.0 °C(Predicted) | [density ]
1.202±0.06 g/cm3(Predicted) | [storage temp. ]
−20°C
| [solubility ]
DMSO: 20 mM | [form ]
A solid | [pka]
12.25±0.46(Predicted) | [color ]
White to light yellow |
| Hazard Information | Back Directory | [Uses]
Biotin-VAD-FMK is a cell permeable, irreversible biotin-labeled caspase inhibitor, used to identify active caspases in cell lysates. | [Biological Activity]
Cell permeable: no''Primary Target
Caspase''Product does not compete with ATP.''Reversible: no | [in vivo]
To examine whether caspase-2 is activated in the absence of proteolytic cleavage, an in vivo affinity labeling approach is used, using the biotinylated caspase inhibitor biotin-VAD-fmk that detects only active caspases[2]. | [IC 50]
Caspase | [References]
[1] Li J, et al. Nitric oxide suppresses apoptosis via interrupting caspase activation and mitochondrial dysfunction in cultured hepatocytes. J Biol Chem. 1999 Jun 11;274(24):17325-33. DOI:10.1074/jbc.274.24.17325
[2] Samraj AK, et al. Loss of caspase-9 reveals its essential role for caspase-2 activation and mitochondrial membranedepolarization. Mol Biol Cell. 2007 Jan;18(1):84-93. DOI:10.1091/mbc.e06-04-0263 |
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| Company Name: |
Alabiotech Inc.
|
| Tel: |
001-619-354-5251 |
| Website: |
www.alabiotech-e.com |
| Company Name: |
cjbscvictory
|
| Tel: |
13348960310 13348960310 |
| Website: |
www.weikeqi-biotech.com/ |
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