| Identification | Back Directory | [Name]
Tenatoprazole | [CAS]
113712-98-4 | [Synonyms]
sulfinyl)
Tenatoprazole
TENATOPRAZOLE 98+%
TENATOPRAZOLE/TU-199
TENATOPRAZOLE MONOSODIUM
5-Methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)
5-methoxy-2-((4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl)-3H-imidazo[4,5-b]pyridine
5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]sulfinyl]-1H-imidazo[4,5-b]pyridine
5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]sulfinyl] -1H-imidazo[4,5-β]pyridine
5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-imidazo[4,5-b]pyridine
5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-imidazo[4,5-β]pyridine
5-Methoxy-2-{[(4-Methoxy-3,5-DiMethyl-2-pyridinyl)Methyl]sulphinyl}- 1H-iMidazo [4,5-b]pyridine
3-Methoxy-8-[(4-methoxy-3,5-dimethyl-pyridin-2-yl)methyl sulfinyl]-2,7,9-triazabicyclo[4.3.0]nona-2,4,8,10-tetraene | [EINECS(EC#)]
601-277-6 | [Molecular Formula]
C16H18N4O3S | [MDL Number]
MFCD08059005 | [MOL File]
113712-98-4.mol | [Molecular Weight]
346.41 |
| Chemical Properties | Back Directory | [Appearance]
White Crystalline Powder | [Melting point ]
178-180°C | [Boiling point ]
570.4±60.0 °C(Predicted) | [density ]
1.43±0.1 g/cm3(Predicted) | [storage temp. ]
−20°C | [solubility ]
DMSO (Slightly, Heated), Methanol (Slightly, Heated) | [form ]
Solid | [pka]
4.61±0.40(Predicted) | [color ]
Off-White to Light Pink | [Stability:]
Hygroscopic, Temperature Sensitive |
| Hazard Information | Back Directory | [Chemical Properties]
White Crystalline Powder | [Uses]
A proton pump inhibitor for reduction and/or prevention of gastrointestinal disorders | [Description]
Tenatoprazole is a proton pump inhibitor, blocking hog gastric H+/K+-ATPase activity with an IC50 value of 6.2 μM.1 It is orally bioavailable, blocking induced gastric acid secretion and ulcer formation in rats and humans.1,2,3 Tenatoprazole has a prolonged plasma half-life resulting in persistent effectiveness after withdrawal.3 | [Definition]
ChEBI: 5-methoxy-2-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methylsulfinyl]-1H-imidazo[4,5-b]pyridine is an imidazopyridine. | [References]
[1] K UCHIYAMA. Effects of TU-199, a novel H+, K(+)-ATPase inhibitor, on gastric acid secretion and gastroduodenal ulcers in rats.[J]. Methods and findings in experimental and clinical pharmacology, 1999, 21 2: 115-122. DOI: 10.1358/mf.1999.21.2.529238
[2] J. P. GALMICHE. Tenatoprazole, a novel proton pump inhibitor with a prolonged plasma half-life: effects on intragastric pH and comparison with esomeprazole in healthy volunteers[J]. Alimentary Pharmacology & Therapeutics, 2004, 19 6: 655-662. DOI: 10.1111/j.1365-2036.2004.01893.x
[3] RICHARD H HUNT. Effect on intragastric pH of a PPI with a prolonged plasma half-life: comparison between tenatoprazole and esomeprazole on the duration of acid suppression in healthy male volunteers.[J]. American Journal of Gastroenterology, 2005, 100 9: 1949-1956. DOI: 10.1111/j.1572-0241.2005.41956.x |
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