113778-69-1

6638-79-5

79-30-1

113778-69-1

I. Synthesis of N-methoxy-N,2-dimethylpropionamide. Isobutyryl chloride (6.02 mL, 57.5 mmol) was added slowly and dropwise to a solution of N,O-dimethylhydroxylamine hydrochloride (5.61 g, 57.5 mmol) and triethylamine (17.6 mL, 126.5 mmol) in dichloromethane (100 mL). The reaction mixture was stirred at room temperature overnight. After completion of the reaction, the reaction mixture was washed with deionized water (100 mL) and the organic layer was dried with anhydrous magnesium sulfate. The solvent was removed by concentration under reduced pressure and the crude product was purified by silica gel column chromatography (eluent: n-hexane to 9:1 n-hexane/ethyl acetate) to afford N-methoxy-N,2-dimethylpropanamide (5.55 g, 74% yield).1H NMR (300 MHz, DMSO-d6) δ 3.72 (s, 3H), 3.31 (m, 1H), 3.18 (s, 3H) 1.09 (d, J = 6.87 Hz, 6H).