| Identification | Back Directory | [Name]
RM 49 | [CAS]
113785-48-1 | [Synonyms]
RM 49
Azirino[2',3':3,4]pyrrolo[1,2-a]indole-8-methanol, 1,1a,2,8,8a,8b-hexahydro-7-hydroxy-4,8a-dimethoxy-5-methyl-6-nitroso-, α-carbamate, (1aS,8S,8aR,8bS)- (9CI) | [Molecular Formula]
C16H20N4O6 | [MOL File]
113785-48-1.mol | [Molecular Weight]
364.35 |
| Hazard Information | Back Directory | [Description]
RM 49 is a mitomycin C derivative that has proven to have in vitro antitumor activity. | [Uses]
RM 49 is the derivative of Mitomycin C (HY-13316). RM 49 exhibits cytotoxicity in SCLC and NSCLC lung cancer cells with IC50 of 0.01-0.5 μg/mL. RM 49 exhibits high relative antitumor activity in compared with Mitomycin C, Cisplatin (HY-17394), Carboplatin (HY-17393) and Doxorubicin (HY-15142)[1]. | [References]
[1] Horiuchi N, et al., In vitro antitumor activity of mitomycin C derivative (RM-49) and new anticancer antibiotics (FK973) against lung cancer cell lines determined by tetrazolium dye (MTT) assay. Cancer Chemother Pharmacol. 1988;22(3):246-50. DOI:10.1007/BF00273419 |
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| Company Name: |
CHEMICAL LAND21
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| Tel: |
82- 2 -783 - 8063 |
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www.chemicalland21.com |
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