| Identification | Back Directory | [Name]
TAK-960 (hydrochloride) | [CAS]
1137868-96-2 | [Synonyms]
TAK-960 HCl
TAK-960 HCl salt
TAK-960 (hydrochloride)
4-[(9-Cyclopentyl-7,7-difluoro-6,7,8,9-tetrahydro-5-methyl-6-oxo-5H-pyrimido[4,5-b][1,4]diazepin-2-yl)amino]-2-fluoro-5-methoxy-N-(1-methyl-4-piperidinyl)benzamide hydrochloride | [Molecular Formula]
C27H35ClF3N7O3 | [MOL File]
1137868-96-2.mol | [Molecular Weight]
598.07 |
| Hazard Information | Back Directory | [Uses]
TAK 960 Hydrochloride is a Polo-like kinase inhibitor. | [in vivo]
TAK-960 hydrochloride exhibits (10 mg/kg; p.o.; once daily for 2 weeks) significant efficacy against multiple tumor xenografts[1].
In animal models, TAK-960 hydrochloride (p.o.) increases pHH3 in a dose-dependent manner and significantly inhibits the growth of HT-29 colorectal cancer xenografts[1]. | Animal Model: | nude mice or SCID mice (bearing HCT116, PC-3, BT474, A549, NCI-H1299, NCI-H1975, A2780, and MV4-11 cells)[1] | | Dosage: | 10 mg/kg | | Administration: | P.o.; once daily for 2 weeks | | Result: | Substantial antitumor activity and good tolerability.
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| [IC 50]
PLK1: 0.8 nM (IC50); PLK2: 16.9 nM (IC50); PLK3: 50.2 nM (IC50); FAK/PTK2: 19.6 nM (IC50); MLCK/MYLK: 25.6 nM (IC50); FES/FPS: 58.2 nM (IC50) | [storage]
Store at -20°C |
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| Company Name: |
Musechem
|
| Tel: |
+1-800-259-7612 |
| Website: |
www.musechem.com |
| Company Name: |
BOC Sciences
|
| Tel: |
16314854226 |
| Website: |
www.bocsci.com |
|