| Identification | Back Directory | [Name]
PYR-VAL-ASN-PHE-SER-THR-GLY-TRP-NH2 | [CAS]
113800-65-0 | [Synonyms]
AKH
AKH-G
PYR-VNFSTGW-NH2
GRYLLUS BIMACULATUS
ADIPOKINETIC HORMONE
ADIPOKINETIC HORMONE G
AKH-G (GRYLLUS BIMACULATUS)
Adipokinetic Hormone, G (AKH-G)
PYR-VAL-ASN-PHE-SER-THR-GLY-TRP-NH2
ADIPOKINETIC HORMONE G (GRYLLUS BIMACULATUS)
AKH, Adipokinetic Hormone, Gryllus bimaculatus
Adipokinetic Hormone G (Gryllus bimaculatus) Pyr-Val-Asn-Phe-Ser-Thr-Gly-Trp-NH2
L-Tryptophanamide, 5-oxo-L-prolyl-L-valyl-L-asparaginyl-L-phenylalanyl-L-seryl-L-threonylglycyl- | [Molecular Formula]
C43H57N11O12 | [MDL Number]
MFCD00076612 | [MOL File]
113800-65-0.mol | [Molecular Weight]
919.98 |
| Chemical Properties | Back Directory | [Boiling point ]
1562.5±65.0 °C(Predicted) | [density ]
1.373±0.06 g/cm3(Predicted) | [storage temp. ]
-15°C | [pka]
12.89±0.46(Predicted) | [Water Solubility ]
Soluble in water |
| Hazard Information | Back Directory | [Uses]
Adipokinetic hormone Gryllus bimaculatus (Grybi-AKH) is an adipokinetic hormone that regulates energy homeostasis in insects by mobilizing lipid and carbohydrate from the fat body. Adipokinetic hormone Gryllus bimaculatus stimulates the locomotor activity of the two-spotted cricket. Adipokinetic hormone Gryllus bimaculatus can also be used in studies to regulate body weight, induce weight loss and alleviate glycogen storage disorders in humans[1][2][3]. | [in vivo]
Adipokinetic hormone Gryllus bimaculatus (100 pmol/per; topical application; single) stimulates locomotory activity via the increase of haemolymph lipid titres[1]. | Animal Model: | 3-day-old adult female Gryllus bimaculatus (Ensifera, Gryllidae)[1]. | | Dosage: | 100 pmol/per | | Administration: | Topical application onto the surface of the dorsal thorax under the wings | | Result: | Resulted in a rapid increase in haemolymph lipid titres. |
| [References]
[1] Lorenz M W, et al. Lipid mobilization and locomotor stimulation in Gryllus bimaculatus by topically applied adipokinetic hormone[J]. Physiological Entomology, 2004, 29(2): 146-151.
[2] Zhou YJ, et al. Effects of adipokinetic hormone and its related peptide on maintaining hemolymph carbohydrate and lipid levels in the two-spotted cricket, Gryllus bimaculatus. Biosci Biotechnol Biochem. 2018 Feb;82(2):274-284. DOI:10.1080/09168451.2017.1422106
[3] Bernice Z. Schacter, et al. Compositions and methods for promoting lipid mobilization, glycogen mobilization, or both, in humans. Patent WO2003066080A1. |
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