| Identification | Back Directory | [Name]
9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine | [CAS]
113852-41-8 | [Synonyms]
GS 0573
9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine
Phosphonic acid, P-[[2-(2,6-diamino-9H-purin-9-yl)ethoxy]methyl]-
sarcoma,replication,CMV,PMEDAP,Inhibitor,HIV,inhibit,mice,Human immunodeficiency virus,Cytomegalovirus,mortality,virus | [Molecular Formula]
C8H13N6O4P | [MOL File]
113852-41-8.mol | [Molecular Weight]
288.2 |
| Chemical Properties | Back Directory | [Boiling point ]
748.7±70.0 °C(Predicted) | [density ]
2.03±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
0.1 M NaOH : 14.29 mg/mL (49.58 mM; ultrasonic and adjust pH to 12 with NaOH) | [form ]
Solid | [pka]
2.37±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
PMEDAP is a potent inhibitor of human immunodeficiency virus (HIV) replication. PMEDAP has anti-murine cytomegalovirus (MCMV) activity. PMEDAP is a very potent inhibitor of Moloney murine sarcoma virus (MSV)-induced tumor formation and associated mortality[1][2]. | [in vivo]
PMEDAP (0.25-5 mg/kg; IP; daily; starting on the day of MSV-infected and continuing for an additional four days) causes a dose-dependent suppression of tumor formation and mortality in newborn mice inoculated with MSV[1]. | Animal Model: | Three-week-old male NMRI mice[1] | | Dosage: | 0.25 mg/kg, 1 mg/kg, 5 mg/kg | | Administration: | IP; daily; starting on the day of infection and continuing for an additional four days | | Result: | Effected a significant delay in tumor appearance and an enhancement of the survival rate of tumor-bearing mice.
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| [storage]
Store at -20°C | [References]
[1] Neyts J, et al. Activity of the anti-HIV agent 9-(2-phosphonyl-methoxyethyl)-2,6-diaminopurine against cytomegalovirus in vitro and in vivo [published correction appears in Eur J Clin Microbiol Infect Dis 1993 Jul;12(7):following 477]. Eur J Clin Microbiol Infect Dis. 1993;12(6):437-446. DOI:10.1007/BF01967438
[2] Naesens L, et al. 9-(2-Phosphonylmethoxyethyl)-2,6-diaminopurine (PMEDAP): a novel agent with anti-human immunodeficiency virus activity in vitro and potent anti-Moloney murine sarcoma virus activity in vivo. Eur J Clin Microbiol Infect Dis. 1989;8(12):1043-1047. DOI:10.1007/BF01975167 |
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