| Identification | Back Directory | [Name]
3-HYDROXY-6H-DIBENZO[B,D]PYRAN-6-ONE | [CAS]
1139-83-9 | [Synonyms]
AURORA 226
Urolithin B
AKOS BBS-00008028
3-hydroxy urolithin
3-hydroxybenzo[c]chromen-6-one
3-hydroxy-6-benzo[c]chromenone
3-Hydroxy-benzo[c]chromen-6-one
3-HYDROXY-6H-DIBENZO[B,D]PYRAN-6-ONE
6H-Dibenzo(b,d)pyran-6-one, 3-hydroxy-
3-Hydroxy-6H-benzo[c]chromen-6-one AldrichCPR | [Molecular Formula]
C13H8O3 | [MDL Number]
MFCD00034338 | [MOL File]
1139-83-9.mol | [Molecular Weight]
212.2 |
| Chemical Properties | Back Directory | [Melting point ]
247 °C | [Boiling point ]
432.6±24.0 °C(Predicted) | [density ]
1.395±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: soluble5mg/mL, clear (warmed) | [form ]
powder | [pka]
9.03±0.20(Predicted) | [color ]
white to beige | [Stability:]
Hygroscopic | [InChI]
InChI=1S/C13H8O3/c14-8-5-6-10-9-3-1-2-4-11(9)13(15)16-12(10)7-8/h1-7,14H | [InChIKey]
WXUQMTRHPNOXBV-UHFFFAOYSA-N | [SMILES]
C12=CC(O)=CC=C1C1=CC=CC=C1C(=O)O2 | [LogP]
2.947 (est) |
| Hazard Information | Back Directory | [Uses]
Urolithin B is an intestinal microbial metabolite of ellagitannis and exhibits potent anti-oxidant and pro-oxidant activies depending on the assay system and conditions. Urolithin B can also display estrogenic and/or anti-estrogenic activity. | [Definition]
ChEBI: Urolithin B is a member of coumarins. | [Biochem/physiol Actions]
Urolithin B is a natural product with antiproliferative and antioxidant activity. Urolithin B is formed by metabolism from polyphenols found in some nuts and fruits, particularly pomegranates. Urolithin B has been shown to cross the blood brain barrier, and may have neuroprotective effects against Alzheimer′s Disease. | [in vivo]
Urolithin B (50 mg/kg; ip; once daily for 4 days) inhibits microglial activation in LPS-injected mouse brains, under neuroinflammatory condition[1].
Urolithin B (10 μg/day; mini-osmotic pump delivery, 28 days) induces muscle hypertrophy and reduces muscle atrophy after sciatic nerve transection in mice[2].
| [IC 50]
Human Endogenous Metabolite |
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