| Identification | Back Directory | [Name]
GSK-3β Inhibitor XVIII | [CAS]
1139875-74-3 | [Synonyms]
GSK3β-IN-1a
GSK3β Inhibitor XVIII
GSK-3β Inhibitor XVIII
GSK-3β Inhibitor XVIII - CAS 1139875-74-3 - Calbiochem | [Molecular Formula]
C20H20ClN5OS | [MDL Number]
MFCD32671859 | [MOL File]
1139875-74-3.mol | [Molecular Weight]
413.92 |
| Chemical Properties | Back Directory | [Boiling point ]
632.3±65.0 °C(Predicted) | [density ]
1.358±0.06 g/cm3(Predicted) | [storage temp. ]
+2C to +8C | [solubility ]
DMSO: soluble | [form ]
White solid | [pka]
6?+-.0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
GSK3β inhibitor XVIII is an inhibitor of glycogen synthase kinase 3β (GSK3β; IC50 = 64 nM). It induces expression of a luciferase reporter in HEK293 cells expressing wild-type Wnt (EC50 = ~1.25 μM) but not in cells expressing a β-catenin/TCF binding site-mutant Wnt. GSK3β inhibitor XVIII increases β-catenin accumulation in the nucleus of HEK293 cells. It induces proliferation of R7T1 β-cells (EC50 = 1,143 nM), an effect that can be blocked by the COX and Wnt signaling inhibitor sulindac , and rat primary β-cells. | [Uses]
GSK-3β inhibitor 8, a thiophenacil derivative, is an effective and selective inhibitor of GSK-3β (IC50=64 nM). GSK-3β inhibitor 8 negatively regulated Wnt signaling pathway and stimulated β cell proliferation[1][2]. | [IC 50]
GSK-3β: 64 nM (IC50) | [References]
[1] Wang W, et al. Identification of small-molecule inducers of pancreatic beta-cell expansion. Proc Natl Acad Sci U S A. 2009 Feb 3;106(5):1427-32. DOI:10.1073/pnas.0811848106 |
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| Company Name: |
BOC Sciences
|
| Tel: |
16314854226 |
| Website: |
www.bocsci.com |
| Company Name: |
Enzo Biochem Inc
|
| Tel: |
Enzo Biochem Inc. 13797054060 |
| Website: |
www.enzo.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|