| Identification | Back Directory | [Name]
1-benzyl-2,3-dimethylguanidinium sulphate (2:1) | [CAS]
114-85-2 | [Synonyms]
Batel
Esbatal
EusManid
Hypersin
Bethanid
Tenathan
Bendogen
Benzaidin
Betanidol
BW 467C60
NSC 106563
Betanidole
Benzanidin
Benzanidine
Betanidine sulfate
BETHANIDINE SULFATE
Bethanidine heMisulfate
1-benzyl-2,3-dimethylguanidinium sulphate (2:1)
Guanidine, N,N-dimethyl-N-(phenylmethyl)-, sulfate (2:1) | [EINECS(EC#)]
204-056-9 | [Molecular Formula]
C10H17N3O4S | [MDL Number]
MFCD01724438 | [MOL File]
114-85-2.mol | [Molecular Weight]
275.32 |
| Chemical Properties | Back Directory | [Melting point ]
>262oC (dec.) | [storage temp. ]
Amber Vial, -20°C Freezer, Under inert atmosphere | [solubility ]
Methanol (Slightly), Water (Slightly) | [form ]
Solid | [color ]
White to Off-White | [Stability:]
Hygroscopic, Light Sensitive |
| Hazard Information | Back Directory | [Originator]
Bendogen,Lagap
Pharmaceuticals SA | [Uses]
Antihypertensive. | [Manufacturing Process]
A mixture of 2-bromobenzylamine (12.5 g) and S-methylthiouronium sulfate
(10 g) in water (20 ml) was heated for 1.5 hours on a steam bath in a hood,
during which methylmercaptan escaped (as evidenced by a foul odour). The
reaction mixture was then cooled and diluted with ethanol (100 ml). A
colourless solid of 2-bromobenzylguanidine sulfate was separeted, and washed
with ethanol. This solid melted at 230-232°C; it was recrystallized from water
and then melted at 247-248°C. By action of a basic agent the salt obtained
may be converted into free base. | [Brand name]
Tenathan (Robins). | [Therapeutic Function]
Antihypertensive | [Safety Profile]
Poison by intraperitoneal,subcutaneous, and intravenous routes. Moderately toxicby ingestion. When heated todecomposition it emits toxic fumes of NOx and SOx. | [Safety Profile]
Poison by subcutaneous andintraperitoneal routes. Moderately toxic by ingestion.When heated to decomposition it emits toxic fumes ofSOx and NOx. |
| Safety Data | Back Directory | [Toxicity]
LD50 in mice (mg/kg): 12 i.v.; 150 i.p.; 260 s.c.; 520 by stomach intubation (Boura, Green) |
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