| Identification | Back Directory | [Name]
6-ACETAMIDO-4-HYDROXY-2-METHYLQUINOLINE | [CAS]
1140-81-4 | [Synonyms]
6-Acetamido-2-methyl-4-hydroxyquinoline
6-ACETAMIDO-4-HYDROXY-2-METHYLQUINOLINE
N-Acetyl-4-hydroxy-2-methyl-6-quinolinamine
N-(4-hydroxy-2-Methylquinolin-6-yl)acetaMide
N-(4-Hydroxy-2-methyl-6-quinolinyl)acetamide
N-(2-methyl-4-oxo-1H-quinolin-6-yl)acetamide
Acetamide, N-(4-hydroxy-2-methyl-6-quinolinyl)-
n-(2-Methyl-4-oxo-1,4-dihydroquinolin-6-yl)acetamide | [Molecular Formula]
C12H12N2O2 | [MOL File]
1140-81-4.mol | [Molecular Weight]
216.24 |
| Chemical Properties | Back Directory | [Melting point ]
>300 °C | [Boiling point ]
496.0±40.0 °C(Predicted) | [density ]
1.314±0.06 g/cm3(Predicted) | [solubility ]
Ethyl Acetate; Toluene | [form ]
Solid | [pka]
4.29±0.40(Predicted) | [color ]
Yellow |
| Hazard Information | Back Directory | [Uses]
N-(4-Hydroxy-2-methyl-6-quinolinyl)acetamide is an intermediate in the synthesis of NSC 23766 (N900280), which is a highly soluble and membrane permeable Rac GTPase inhibitor. NSC 23766 inhibits Rac GTPase by targeting Rac activation by guanine nucleotide exchange factor (GEF). NSC 23766 has been shown to inhibit the anchorage-independent growth and invasion phenotypes of human prostate cancer PC-3 cells. | [Synthesis Reference(s)]
Journal of the American Chemical Society, 70, p. 4065, 1948 DOI: 10.1021/ja01192a031 |
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