ChemicalBook--->CAS DataBase List--->114037-60-4

114037-60-4

114037-60-4 Structure

114037-60-4 Structure
IdentificationBack Directory
[Name]

SR 43845
[CAS]

114037-60-4
[Synonyms]

SR 43845
3-Ethyl-N-[1,1-bis(hydroxymethyl)ethyl]-Nα-[(3S,4S)-5-cyclohexyl-3-hydroxy-4-[[N-[3-(3-pyridinyl)-1-oxopropyl]-L-Phe-L-His-]amino]pentanoyl]-L-norvalinamide
N-[1-Oxo-3-(3-pyridinyl)propyl]-L-phenylalanyl-L-histidyl-4-amino-5-cyclohexyl-2,4,5-trideoxy-L-threo-pentonoyl-N-[2-hydroxy-1-(hydroxymethyl)-1-methylethyl]-L-isoleucinamide
L-Isoleucinamide, N-[1-oxo-3-(3-pyridinyl)propyl]-L-phenylalanyl-L-histidyl-4-amino-5-cyclohexyl-2,4,5-trideoxy-L-threo-pentonoyl-N-[2-hydroxy-1-(hydroxymethyl)-1-methylethyl]-
[Molecular Formula]

C44H64N8O8
[MDL Number]

MFCD00887763
[MOL File]

114037-60-4.mol
[Molecular Weight]

833.038
Chemical PropertiesBack Directory
[Boiling point ]

1225.7±65.0 °C(Predicted)
[density ]

1.227±0.06 g/cm3(Predicted)
[pka]

13.66±0.20(Predicted)
Hazard InformationBack Directory
[Uses]

SR 43845 is a renin inhibitor. SR 43845 decreases blood pressure and inhibits plasma renin activity. SR 43845 can be used for hypertension research[1].
[References]

[1] Lacour C, et al. Effects of a renin inhibitor, SR 43845, and of captopril on blood pressure and plasma active renin in conscious sodium-replete macaca. J Hypertens Suppl. 1989 Apr;7(2):S33-5. DOI:10.1097/00004872-198904002-00008
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