| Identification | Back Directory | [Name]
BMS-823778
(BMS823778) | [CAS]
1140898-87-8 | [Synonyms]
BMS-823778
BMS-823778
(BMS823778)
BMS-823778 >=98% (HPLC)
BMS 823778 hydrochloride | [Molecular Formula]
C18H19Cl2N3O | [MDL Number]
MFCD30718574 | [MOL File]
1140898-87-8.mol | [Molecular Weight]
364.27 |
| Hazard Information | Back Directory | [Uses]
BMS 823778 is a potent and selective inhibitor of human 11β-?hydroxysteroid dehydrogenase type 1 (11β-?HSD-?1) enzyme. | [in vivo]
BMS-823778 (10-100 mg/kg; oral; once) hydrochloride exhibits robust acute pharmacodynamic effects in diet-induced obese (DIO) mice (ED50=34 mg/kg) [1]. | Animal Model: | Diet-induced obese (DIO) mice[1] | | Dosage: | 10-100 mg/kg | | Administration: | Oral, once | | Result: | Inhibition of 11β-HSD-1 was observed as a measure of decrease in the plasma concentration of corticosterone. The ED50 was 34 mg/kg.
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| Animal Model: | Male Balb/C mice[1] | | Dosage: | 5 or 10 mg/kg | | Administration: | IV or PO (Pharmacokinetic Analysis) | | Result: | Single-Dose Pharmacokinetic Parameters of BMS-823778[1]
| Species | Route | Dose (mg/kg) | Cmax (μM) | Tmax (h) | AUC(0-24 h) (μM?h) | T1/2 (h) | CLTp (mL/min/kg) | Vss (L/kg) | F (%) | | Mouse | IV* | 5 | - | - | 106 | 5.2 | 2.3 | 1.2 | - | | PO** | 10 | 10.6 ± 1.3 | 3 | 95 | - | - | - | 44 |
*PO Vehicle: 0.5% Methocel/0.1% Tween 80
** IV vehicle: 10% ethanol/30% propylene glycol/60% normal saline
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| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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