| Identification | Back Directory | [Name]
PVZB-1194 | [CAS]
1141768-04-8 | [Synonyms]
PVZB-1194
[1,1'-Biphenyl]-4-sulfonamide, 3'-fluoro-4'-(trifluoromethyl)- | [Molecular Formula]
C13H9F4NO2S | [MDL Number]
MFCD20230229 | [MOL File]
1141768-04-8.mol | [Molecular Weight]
319.27 |
| Chemical Properties | Back Directory | [Boiling point ]
417.0±55.0 °C(Predicted) | [density ]
1.442±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
9.91±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
PVZB1194 is a biphenyl-type
inhibitor of Kinesin-5 ATPase activity that binds to the α4/α6 site of the motor domain in a nucleotide competitive manner. PVZB1194 has an IC50 of 0.12 μM for KSP ATPase. PVZB1194 induces mitotic arrest with the formation of a monopolar spindle, and inhibits HeLa cells proliferatio (IC50: 5.5 μM). PVZB1194 can be used in the study of tumors[1][2]. | [IC 50]
Eg5 | [References]
[1] Sawada JI, et al. Various effects of two types of kinesin-5 inhibitors on mitosis and cell proliferation. Biochem Pharmacol. 2021 Nov;193:114789. DOI:10.1016/j.bcp.2021.114789
[2] Matsuno K, et al. Bis(hetero)aryl derivatives as unique kinesin spindle protein inhibitors. Bioorg Med Chem Lett. 2009 Feb 15;19(4):1058-61. DOI:10.1016/j.bmcl.2009.01.018 |
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