| Identification | Back Directory | [Name]
Benzamide, N-[1-(1,1-dimethylethyl)-3-[[(2S)-2-(1-pyrrolidinylmethyl)-1-pyrrolidinyl]carbonyl]-1H-pyrazolo[3,4-d]thiazol-5-yl]-4-methyl- | [CAS]
1142050-84-7 | [Synonyms]
LP403812
LP-403812
LP 403812
Benzamide, N-[1-(1,1-dimethylethyl)-3-[[(2S)-2-(1-pyrrolidinylmethyl)-1-pyrrolidinyl]carbonyl]-1H-pyrazolo[3,4-d]thiazol-5-yl]-4-methyl- | [Molecular Formula]
C26H34N6O2S | [MOL File]
1142050-84-7.mol | [Molecular Weight]
494.65 |
| Hazard Information | Back Directory | [Description]
LP-403812 is a potent small molecule inhibitors of the high affinity proline transporter. | [Uses]
LP-403812 is a high affinity proline transporter (PROT) inhibitor that produces dose-dependent inhibition of hPROT (IC50=0.11 μM; Ki=0.12 μM) and also inhibits the activity of mouse brain synaptosomal mPROT with the same potency (IC50=0.23 μM). LP-403812 can be used to study the function of PROT in the brain[1]. | [References]
[1] XuanChuan Yu, et al. "Discovery and characterization of potent small molecule inhibitors of the high affinity proline transporter." Neuroscience letters 451.3 (2009): 212-216. DOI:10.1016/j.neulet.2009.01.018 |
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