| Identification | Back Directory | [Name]
Urea, N-[4-[4-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)thieno[3,2-d]pyrimidin-2-yl]phenyl]-N'-3-pyridinyl- | [CAS]
1144075-44-4 | [Synonyms]
mTOR inhibitor 13
Urea, N-[4-[4-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)thieno[3,2-d]pyrimidin-2-yl]phenyl]-N'-3-pyridinyl-
Urea, N ?[4 ?[4 ?(8 ?oxa ?3 ?azabicyclo[3.2.1]?oct ?3 ?yl)?thieno[3,?2 ?d]?pyrimidin ?2 ?yl]?phenyl]? ?N' ?3 ?pyridinyl ,Urea, N?[4?[4?(8?oxa?3?azabicyclo[3.2.1]?oct?3?yl)?thieno[3,?2?d]?pyrimidin?2?yl]?phenyl]??N'?3?pyridinyl | [Molecular Formula]
C24H22N6O2S | [MOL File]
1144075-44-4.mol | [Molecular Weight]
458.54 |
| Hazard Information | Back Directory | [Uses]
mTOR inhibitor-13 (compound 9g), an aryl ureido compound, is a potent and selective mTOR inhibitor with an IC50 of 0.29 nM. mTOR inhibitor-13 also inhibits PI3K-α with an IC50 of 119 nM[1]. | [IC 50]
mTOR: 0.29 nM (IC50); PI3Kα: 119 nM (IC50) | [References]
[1] Jeroen C Verheijen, et al. Discovery of 2-arylthieno[3,2-d]pyrimidines containing 8-oxa-3-azabi-cyclo[3.2.1]octane in the 4-position as potent inhibitors of mTOR with selectivity over PI3K. Bioorg Med Chem Lett. 2010 Jan 1;20(1):375-9. DOI:10.1016/j.bmcl.2009.10.075 |
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