| Identification | Back Directory | [Name]
2-AMINO-3-HYDROXY-4-BROMOPYRIDINE HBR | [CAS]
114414-17-4 | [Synonyms]
2-AMino-3-hydroxy-4-broMopydine HBr
2-AMINO-3-HYDROXY-4-BROMOPYRIDINE HBR
2-Amino-4-bromo-3-hydroxypyridine hbr
2-amino-4-bromo-3-pyridinol hydrobromide
2-AMino-4-broMopyridin-3-ol hydrobroMide
2-Amino-4-bromo-3-pyridinol monohydrobromide
2-AMINO-3-HYDROXY-4-BROMOPYRIDINE HYDROBROMIDE | [Molecular Formula]
C5H6Br2N2O | [MDL Number]
MFCD09842810 | [MOL File]
114414-17-4.mol | [Molecular Weight]
269.922 |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of 2-amino-4-bromopyridin-3-ol hydrobromide from 2-amino-3-hydroxypyridine: Bromine (11.2 mL, 0.21 mol) was slowly added dropwise to a mechanically stirred suspension of 2-amino-3-hydroxypyridine (20 g, 0.18 mol) in acetic acid (300 mL) at 5-10 °C, after which the reaction system was brought to room temperature. The reaction mixture was heated to 120-125 °C, maintained for 12 h and then concentrated to give the crude product. The crude product was ground with ether (50 mL x 3) and subsequently dried under vacuum to afford 2-amino-4-bromopyridin-3-ol hydrobromide as a dark brown solid, which could be used in subsequent reactions without further purification. Yield: 48.5 g; MS (m/z): 189.3, 191.1 ([M + H]+). | [References]
[1] Patent: WO2018/42362, 2018, A1. Location in patent: Page/Page column 125 |
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