| Identification | Back Directory | [Name]
Kisspeptin 234 | [CAS]
1145998-81-7 | [Synonyms]
Kisspeptin 234
L-Phenylalaninamide, N-acetyl-D-alanyl-L-asparaginyl-L-tryptophyl-L-asparaginylglycyl-L-phenylalanylglycyl-D-tryptophyl-L-arginyl- | [Molecular Formula]
C63H78N18O13 | [MOL File]
1145998-81-7.mol | [Molecular Weight]
1295.41 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
insoluble in DMSO; insoluble in EtOH; ≥4.44 mg/mL in H2O with ultrasonic | [form ]
solid | [color ]
White | [Water Solubility ]
Soluble to 1 mg/ml in water | [Sequence]
Ac-d-Ala-Asn-Trp-Asn-Gly-Phe-Gly-d-Trp-Arg-Phe-NH2 |
| Hazard Information | Back Directory | [Uses]
Kisspeptin 234, is a 10 amino acid peptide as well as a kisspeptin receptor (KISS1, GPR54) antagonist. Kisspeptin 234 is an analog of Kisspeptin 10[1]. | [Biological Activity]
kisspeptin 234 is a kisspeptin receptor antagonist, with the ability to antagonize kisspeptin-10-induced activation of gpr-54. kisspeptin binds to its cognate receptor (i.e. gpr-54) on neurons that produce gonadotropin-releasing hormone (gnrh), and stimulates their activity, which in turn sends an obligatory signal for gnrh secretion, thereby gating down-stream events supporting reproduction. the development of kisspeptin receptor antagonists may provide a valuable tool for exploring the physiological and pathophysiological roles of kisspeptin in the regulation of reproduction, and could serve as a potential therapeutic agent for treating hormone-dependent disorders of reproduction, such as precocious puberty, endometriosis, as well as metastatic prostate cancer.1. roseweir ak, kauffman as, smith jt, et al. discovery of potent kisspeptin antagonists delineate physiological mechanisms of gonadotropin regulation. journal of neuroscience, 2009, 29(12): 3920-3929. | [in vivo]
Kisspeptin 234 (1 mg/kg, ip, daily, 28 days) TFA can inhibit the anti-fibrotic effect of Kisspeptin-13 in the bleomycin (BLM)-induced lung fibrosis model of C57BL/6 mice, especially in weight loss, decreased survival rate, increased lung coefficient, and massive infiltration[1].
| [storage]
Store at -20°C | [References]
[1] Lei Z, et al. Kisspeptin?13 inhibits bleomycin?induced pulmonary fibrosis through GPR54 in mice. Mol Med Rep. 2019 Aug;20(2):1049-1056. DOI:10.3892/mmr.2019.10341 |
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