| Identification | Back Directory | [Name]
SDZ MKS 492 | [CAS]
114606-56-3 | [Synonyms]
MKS 492
SDZ MKS 492
1H-Purine-2,6-dione, 8-[[(1R)-1-(3,4-dimethoxyphenyl)-2-hydroxyethyl]amino]-3,7-dihydro-7-(2-methoxyethyl)-1,3-dimethyl- | [Molecular Formula]
C20H27N5O6 | [MDL Number]
MFCD00898843 | [MOL File]
114606-56-3.mol | [Molecular Weight]
433.46 |
| Chemical Properties | Back Directory | [Boiling point ]
648.7±65.0 °C(Predicted) | [density ]
1.36±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 250 mg/mL (576.75 mM; Need ultrasonic) | [form ]
Solid | [pka]
14.25±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
SDZ-MKS 492 (MKS 492) is a selective inhibitor of cyclic GMP-inhibited phosphodiesterase (type III PDE). SDZ-MKS 492 inhibits antigen- or platelet activating factor (PAF)-induced bronchoconstriction and allergic reactions in guinea pigs and rats[1]. | [in vivo]
MKS-492 (3-10 mg/kg; i.v.) inhibits antigen-induced bronchoconstriction in guinea pigs[1].
MKS-492 (1-3 mg/kg; i.v.) inhibits PAF-induced bronchoconstriction and the increase in airway responsiveness to histamine in guinea pigs[1].
MKS-492 (30-100 mg/kg; i.p.) inhibits leukotriene B4 (LTB4)-induced airway eosinophilia in guinea pigs[1].
MKS-492 (10-100 mg/kg; i.p.) inhibits passive cutaneous anaphylaxis and mediator-induced skin reactions in rats[1]. | Animal Model: | Female Hartley guinea pigs (250-300 g) were passively sensitized with anti-BPO BGG guinea pig serum[1] | | Dosage: | 3, 10 mg/kg | | Administration: | I.v. 5 min before antigen challenge | | Result: | Inhibited antigen-induced bron choconstriction in a dose-related manner. |
| [storage]
Store at -20°C | [References]
[1] Nagai H, et al. Effects of MKS-492 on antigen-induced bronchoconstriction and allergic reaction in guinea pigs and rats. Jpn J Pharmacol. 1993 Dec;63(4):405-13. DOI:10.1254/jjp.63.405
[2] Morley J, et, al. SDZ MKS 492. Agents Actions Suppl. 1991;34:403-10. PMID:1793072 |
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