| Identification | Back Directory | [Name]
DHODH-IN-4 | [CAS]
1148125-93-2 | [Synonyms]
DHODH-IN-4
DHODHIN4,DHODH IN 4
2-Butenamide, 2-cyano-N-(2',3-dichloro[1,1'-biphenyl]-4-yl)-3-hydroxy-, (2Z)- | [Molecular Formula]
C17H12Cl2N2O2 | [MDL Number]
MFCD32671343 | [MOL File]
1148125-93-2.mol | [Molecular Weight]
347.2 |
| Chemical Properties | Back Directory | [Melting point ]
112-114 °C(Solv: hexane (110-54-3)) | [Boiling point ]
537.1±50.0 °C(Predicted) | [density ]
1.415±0.06 g/cm3(Predicted) | [pka]
5.20±0.50(Predicted) |
| Hazard Information | Back Directory | [Uses]
DHODH-IN-4 (compound 17) is a human and Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) inhibitor, with IC50 values of 4 μM and 0.18 μM for PfDHODH and HsDHODH, respectively. DHODH-IN-4 (compound 17) possess antimalarial activity[1]. | [References]
[1] Davies M, et al. Structure-based design, synthesis, and characterization of inhibitors of human and Plasmodium falciparum dihydroorotate dehydrogenases. J Med Chem. 2009 May 14;52(9):2683-93. DOI:10.1021/jm800963t |
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