| Identification | Back Directory | [Name]
gamma-preprotachykinin amide (72-92) | [CAS]
114882-65-4 | [Synonyms]
γ-Preprotachykinin(72-92)
g-Preprotachykinin aMide (72-92)
Neuropeptide γ trifluoroacetate salt
gamma-preprotachykinin amide (72-92)
L-Asp-L-Ala-Gly-L-His-Gly-L-Gln-L-Ile-L-Ser-L-His-L-Lys-L-Arg-L-His-L-Lys-L-Thr-L-Asp-L-Ser-L-Phe-L-Val-Gly-L-Leu-L-Met-NH2
L-Methioninamide, L-α-aspartyl-L-alanylglycyl-L-histidylglycyl-L-glutaminyl-L-isoleucyl-L-seryl-L-histidyl-L-lysyl-L-arginyl-L-histidyl-L-lysyl-L-threonyl-L-α-aspartyl-L-seryl-L-phenylalanyl-L-valylglycyl-L-leucyl- | [Molecular Formula]
C99H158N34O29S | [MDL Number]
MFCD00167609 | [MOL File]
114882-65-4.mol | [Molecular Weight]
2320.62 |
| Chemical Properties | Back Directory | [density ]
1.51±0.1 g/cm3(Predicted) | [form ]
Solid | [color ]
White to off-white | [Water Solubility ]
Soluble in water at 2mg/ml. Also soluble in acetonitrile |
| Hazard Information | Back Directory | [Uses]
γ-Neuropeptide (rabbit) can be isolated from rabbit intestine. γ-Neuropeptide is an endogenous neurokinin peptide that acts as a neurokinin 2 (NK2) receptor agonist. γ-Neuropeptide mediates hypothalamic-pituitary-adrenal (HPA) axis, as well as reproductive hormone release[1][2][3]. | [IC 50]
NK2 | [References]
[1] Kage R, et al. Neuropeptide-gamma: a peptide isolated from rabbit intestine that is derived from gamma-preprotachykinin. J Neurochem. 1988 May;50(5):1412-7. DOI:10.1111/j.1471-4159.1988.tb03024.x
[2] Yuan L, et al. Characterization of tachykinin receptors mediating bronchomotor and vasodepressor responses to neuropeptide gamma and substance P in the anaesthetized rabbit. Pulm Pharmacol Ther. 1998 Feb;11(1):31-9. DOI:10.1006/pupt.1998.0112
[3] Debeljuk L, et al. Modulation of the hypothalamo-pituitary-gonadal axis and the pineal gland by neurokinin A, neuropeptide K and neuropeptide gamma. Peptides. 1999;20(2):285-99. DOI:10.1016/s0196-9781(98)00159-4
[4] Kalra PS, et al. Diverse effects of tachykinins on luteinizing hormone release in male rats: mechanism of action. Endocrinology. 1992 Sep;131(3):1195-201. DOI:10.1210/endo.131.3.1380435
[5] Debeljuk L, et al. In vivo and in vitro effects of neuropeptide K and neuropeptide gamma on the release of growth hormone. Neuroreport. 1995 Dec 15;6(18):2457-60. DOI:10.1097/00001756-199512150-00005 |
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