| Identification | Back Directory | [Name]
MUPIROCIN CALCIUM, REFERENCE SPECTRUM EP STANDARD | [CAS]
115074-43-6 | [Synonyms]
Mupirocin Ca
Unii-rg38I2p540
mupirocin calcium hydrate
Mupirocin Calcium (200 mg)
Mupirocin calcium dihydrate
Calcium mupirocin dihydrate
MUPIROCIN CALCIUM, REFERENCE SPECTRUM EP STANDARD
MUPIROCIN CALCIUM, REFERENCE SPECTRUM EP STANDARD###Mupirocin
5,9-ANHYDRO-2,3,4,8-TETRADEOXY-8-[[3-(2-HYDROXY-1-METHYLPROPYL)OXIRANYL]METHYL]-3-METHYL-[2E,8[2S,3S(1S,2S)]]-L-TALONONO
Calcium 9-[(E)-4-[(2S,3R,4R,5S)-3,4-dihydroxy-5-[[(2S,3S)-3-[(2S,3S)-3-hydroxybutan-2-yl]oxiran-2-yl]methyl]oxan-2-yl]-3-methylbut-2-enoyl]oxynonanoate dihydrate
L-talo-Non-2-enonic acid, 5,9-anhydro-2,3,4,8-tetradeoxy-8-[[3-(2-hydroxy-1-methylpropyl)oxiranyl]methyl]-3-methyl-, 8-carboxyoctyl ester, calcium salt (2:1), dihydrate, [2E,8[2S,3S(1S,2S)]]- (9CI) | [EINECS(EC#)]
200-158-5 | [Molecular Formula]
C52H86CaO18.2H2O | [MDL Number]
MFCD01765964 | [MOL File]
115074-43-6.mol | [Molecular Weight]
1075.34 |
| Chemical Properties | Back Directory | [Appearance]
White or almost white powder. | [Melting point ]
132-139 °C | [storage temp. ]
Store at -20°C | [solubility ]
Very slightly soluble in water, sparingly soluble in anhydrous ethanol and in methylene chloride. | [form ]
Solid | [color ]
White to Off-White | [Water Solubility ]
Water: 6 mg/mL (5.58 mM) | [InChIKey]
DDHVILIIHBIMQU-UGPPHRKUNA-L |
| Hazard Information | Back Directory | [Chemical Properties]
White or almost white powder. | [Uses]
Antibacterial (topical). | [Brand name]
Bactroban (GlaxoSmithKline). | [Definition]
ChEBI: Mupirocin calcium hydrate is a hydrate that is the dihydrate form of mupirocin calcium. It is an antibacterial drug used for the treatment of skin infections such as impetigo caused by Staphylococcus aureus and meticillin-resistant Staphylococcus aureus (MRSA). It has a role as an antibacterial drug, a protein synthesis inhibitor and an antiinfective agent. It contains a mupirocin calcium (anhydrous). | [in vivo]
MRSA: Meticillin-resistant Staphylococcus aureus
Mupirocin (BRL-4910A, Pseudomonic acid) calcium is well absorbed after oral and parenteral administration but serum antibiotic concentrations were short-lived as a result of extensive degradation to the antibacterially inactive metabolite, monic acid A[1].
Mupirocin calcium (2% ointment; external administration; twice daily; 3-6 d) decreases the total bacterial loads in the skin lesions with either topical treatment[3].
Mupirocin calcium (2% ointment; external administration; 4 d) alleviates MRSA-infected pressure ulcers in mice[4].
Mupirocin calcium (100 mg/mL; s.c.; 7 d) exerts prevention efficacy against vascular prosthetic graft infection due to Staphylococcus epidermidis[5].
| Animal Model: | MRSA skin infection model in mice (10-12 weeks old)[3] | | Dosage: | 2% ointment | | Administration: | External administration; twice daily; 3-6 days | | Result: | Reduced the total bacterial loads in the skin lesions, and decreased by 2.0, 5.1 log10 CFU on day 3 and 6, respectively.
|
| Animal Model: | Diabetic pressure ulcer mouse model (33.2-39.2 g)[4] | | Dosage: | 2% ointment | | Administration: | External administration; 4 days | | Result: | Resulted less superficial mats of bacterial colonies, and improved histopathology evaluation.
|
| Animal Model: | Adult male Wistar rats (weight 275-325 g)[5] | | Dosage: | Impregnated with 100 μg of mupirocin/mL; segments:1.5 cm *1 cm2 | | Administration: | Subcutaneous implantation; 7 days | | Result: | Resulted in preventing S. epidermidis infection of the graft in a rat model with spontaneously bound to collagen-sealed Dacron grafts.
|
| [storage]
Store at -20°C |
| Safety Data | Back Directory | [WGK Germany ]
3 | [HS Code ]
2941906000 | [Toxicity]
mouse,LD50,intravenous,1638mg/kg (1638mg/kg),Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 27, Pg. 195, 1996. |
|
|