| Identification | Back Directory | [Name]
7-Bromo-2-chlorothieno[3,2-d]pyrimidine | [CAS]
1152475-42-7 | [Synonyms]
7-Bromo-2-chlorothieno[3,2-d]pyrimidine
Thieno[3,2-d]pyrimidine, 7-bromo-2-chloro-
7-Bromo-2-chlorothieno[3,2-d]pyrimidine ISO 9001：2015 REACH | [Molecular Formula]
C6H2BrClN2S | [MDL Number]
MFCD13193398 | [MOL File]
1152475-42-7.mol | [Molecular Weight]
249.52 |
| Chemical Properties | Back Directory | [density ]
1.955 | [storage temp. ]
under inert gas (nitrogen or Argon) at 2–8 °C | [pka]
-0.83±0.40(Predicted) | [Appearance]
White to off-white Solid |
| Hazard Information | Back Directory | [Synthesis]
Compound 1-i (CAS: 1293987-55-9, 500 mg, 2.02 mmol) was used as starting material and dissolved in dichloromethane (5 mL). Subsequently, activated manganese dioxide (270 mg, 3.04 mmol) was added to the solution and the reaction mixture was stirred at room temperature for 3 hours. Upon completion of the reaction, the mixture was filtered through a diatomaceous earth pad and the filter cake was washed with dichloromethane (5 mL, 3 times, 4 mL each). All the filtrates were combined and concentrated under reduced pressure to give a white solid 1-h (430 mg, 86% yield), which was used for subsequent reactions without further purification. The m/z of the product 1-h was measured as m/z = 249 [M + H]+ by LC-MS (ESI) analysis. | [References]
[1] Patent: EP3287463, 2018, A1. Location in patent: Paragraph 0104; 0106
[2] Patent: WO2011/49332, 2011, A2. Location in patent: Page/Page column 17
[3] Patent: US2012/277424, 2012, A1. Location in patent: Page/Page column 8
[4] Patent: US2018/208604, 2018, A1. Location in patent: Paragraph 0368-0369 |
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