| Identification | Back Directory | [Name]
SIGUAZODAN | [CAS]
115344-47-3 | [Synonyms]
SKF 94836
SIGUAZODAN
SK AND F-94836
Siguazodan (SKF 94836)
N-Cyano-Nmethyl-Nⅱ-[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]guanidine
N-CYANO-N'-METHYL-N''-[4-(1,4,5,6-TETRAHYDRO-4-METHYL-6-OXO-3-PYRIDAZINYL)PHENYL]GUANIDINE
4β-Methyl-4,5-dihydro-3-[4-[[(cyanoimino)(methylamino)methyl]amino]phenyl]pyridazin-6(1H)-one
Guanidine, N-cyano-N'-methyl-N''-[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]-
Siguazodan, N-Cyano-Nμ-methyl-N-[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]guanidine
[4R,(-)]-4,5-Dihydro-3-[4-[[(cyanoimino)(methylamino)methyl]amino]phenyl]-4-methylpyridazin-6(1H)-one
[4S,(+)]-4,5-Dihydro-3-[4-[[(cyanoimino)(methylamino)methyl]amino]phenyl]-4-methylpyridazin-6(1H)-one | [Molecular Formula]
C14H16N6O | [MDL Number]
MFCD00867103 | [MOL File]
115344-47-3.mol | [Molecular Weight]
284.32 |
| Chemical Properties | Back Directory | [Melting point ]
268-268.9 °C(lit.)
| [density ]
1.31±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C
| [solubility ]
DMSO: >5 mg/mL, freely soluble
| [form ]
solid
| [pka]
13.71±0.60(Predicted) | [color ]
white
|
| Hazard Information | Back Directory | [Uses]
Siguazodan is a selective phosphodiesterase PDE III inhibitor and a potent inotropic agent. | [Definition]
ChEBI: 1-cyano-2-methyl-3-[4-(4-methyl-6-oxo-4,5-dihydro-1H-pyridazin-3-yl)phenyl]guanidine is a pyridazinone. | [Biological Activity]
Phosphodiesterase inhibitor, selective for PDE3 (IC 50 = 117 nM). | [in vivo]
Siguazodan is a potent, selective inhibitor of phosphodiesterase III that has positive inotropic and vasodilating actions in various laboratory animals and is orally active with a long duration of action in conscious dogs[2]. |
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| Company Name: |
BOC Sciences
|
| Tel: |
|
| Website: |
https://www.bocsci.com |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
InvivoChem
|
| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
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