| Identification | Back Directory | [Name]
Sch 39370 | [CAS]
115406-23-0 | [Synonyms]
Sch 39370
(S)-N-[N-[(S)-1-Carboxy-3-phenylpropyl]-L-phenylalanyl]-2-hydroxy-β-alanine | [Molecular Formula]
C22H26N2O6 | [MDL Number]
MFCD00872826 | [MOL File]
115406-23-0.mol | [Molecular Weight]
414.46 |
| Hazard Information | Back Directory | [Description]
SCH-39370 is a potent and specific inhibitor of neutral metalloendopeptidase (NEP). | [Uses]
SCH-39370 is a potent and specific inhibitor of neutral metalloendopeptidase (NEP) from rabbit kidney with an IC50 value of 11.2 nM. SCH-39370 potentiates biological responses to atrial natriuretic factor and lowers blood pressure in desoxycorticosterone acetate-sodium hypertensive rats[1]. | [References]
[1] Sybertz EJ, et al. SCH 39370, a neutral metalloendopeptidase inhibitor, potentiates biological responses to atrial natriuretic factor and lowers blood pressure in desoxycorticosterone acetate-sodium hypertensive rats. J Pharmacol Exp Ther. 1989 Aug;250(2):624-31. PMID:2547941 |
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