| Identification | Back Directory | [Name]
TMRM | [CAS]
115532-49-5 | [Synonyms]
TMRM.ClO4
6-(dimethylamino)-9-(2-methoxycarbonylphenyl)xanthen-3-ylidene]-dimethylazanium | [Molecular Formula]
C25H25N2O3 | [MDL Number]
MFCD31715459 | [MOL File]
115532-49-5.mol | [Molecular Weight]
401.49 |
| Hazard Information | Back Directory | [Uses]
Rhodamine dyes are membrane-permeable cationic fluorescent probes that specifically recognize mitochondrial membrane potentials, thereby attaching to mitochondria and producing bright fluorescence, and at certain concentrations, rhodamine dyes have low toxicity to cells, so they are commonly used to detect mitochondria in animal cells, plant cells, and microorganisms[1]. | [References]
[1] Crowley LC, et al. Measuring Mitochondrial Transmembrane Potential by TMRE Staining. Cold Spring Harb Protoc. 2016 Dec 1;2016(12):pdb.prot087361. DOI:10.1101/pdb.prot087361
[2] Chowdhury SR, et al. Simultaneous evaluation of substrate-dependent oxygen consumption rates and mitochondrial membrane potential by TMRM and safranin in cortical mitochondria. Biosci Rep. 2015 Dec 8;36(1):e00286. DOI:10.1042/BSR20150244
[3] Monteith A, et al. Imaging of mitochondrial and non-mitochondrial responses in cultured rat hippocampal neurons exposed to micromolar concentrations of TMRM. PLoS One. 2013;8(3):e58059. DOI:10.1371/journal.pone.0058059 |
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