| Identification | Back Directory | [Name]
CytochroMe P450 14a-deMethylase inhibitor 1h | [CAS]
1155361-06-0 | [Synonyms]
CytochroMe P450 14a-deMethylase inhibitor 1h
1H-1,2,4-Triazole-1-ethanol, α-[[[(2-bromophenyl)methyl]-2-propen-1-ylamino]methyl]-α-(2,4-difluorophenyl)- | [Molecular Formula]
C21H21BrF2N4O | [MDL Number]
MFCD18384997 | [MOL File]
1155361-06-0.mol | [Molecular Weight]
463.32 |
| Hazard Information | Back Directory | [Uses]
CYP51-IN-2 (compound 1h), a Fluconazole (HY-B0101) analog, is a potent antifungal agent. CYP51-IN-2 shows MIC80s of 15.6 and 62.5 ng/mL for Microsporum gypseum and Candida albicans, respectively[1]. | [References]
[1] Chai X, et, al. Design, synthesis, and biological evaluation of novel triazole derivatives as inhibitors of cytochrome P450 14alpha-demethylase. Eur J Med Chem. 2009 May;44(5):1913-20. DOI:10.1016/j.ejmech.2008.11.007 |
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