| Identification | Back Directory | [Name]
quinoprazine | [CAS]
115618-99-0 | [Synonyms]
IND2118
quinoprazine
N-(4-(4-Ethylpiperazin-1-yl)phenyl)benzo[g]quinolin-4-amine
Benzo[g]quinolin-4-amine, N-[4-(4-ethyl-1-piperazinyl)phenyl]- | [Molecular Formula]
C25H26N4 | [MDL Number]
MFCD00227004 | [MOL File]
115618-99-0.mol | [Molecular Weight]
382.5 |
| Hazard Information | Back Directory | [Uses]
Quinoprazine is a potent inhibitor of Vaccinia virus DNA synthesis with an IC50 value of 10 μM. Quinoprazine has antimalarial activity against Plasmodium berghei and also displays antiprion potency, significantly decreases PrPSc levels[1]-[5]. | [in vivo]
Quinoprazine is a 1-alkyl-4-[4-(heterylamino)phenyl]piperazines derivate, Quinoprazine (0.25 g/kg; i.p.; single dose) suppresses the growth of larvocysts of Echinococcus multilocularis in cotton rats[5].
Quinoprazine (0.2-0.5 g/kg; p.o.; single dose) acts against the adult Hymenolepis nana. Exptl. and cures infected mice radically[5].
| [References]
[1] Mikha?litsyn FS, et al. The search for new antiparasitic agents. 10. The synthesis, toxicological and antimalarial properties of nitrogen-containing heterocycles with a 4-(4-alkylpiperazinyl-1) phenylamine substituent (the preparation quinoprazine). Med P PMID:1508078
[2] Ricciardi RP, et al. Therapeutic compounds for blocking DNA synthesis of POX viruses: United States, US20100035887[P]. 2010-02-11.
[3] Renslo AR, et al. Preparation of antiprion compounds containing thiazole-amine for treating neurodegenerative diseases: World Intellectual Property Organization, WO2013033037[P]. 2013-03-07.
[4] Silber BM, et al. Antiprion compounds that reduce PrP(Sc) levels in dividing and stationary-phase cells. Bioorg Med Chem. 2013 Dec 15;21(24):7999-8012. DOI:10.1016/j.bmc.2013.09.022
[5] Mikha?litsyn FS, et al. The search for new antiparasitic agents. 8. The synthesis and study of the acute toxicity, anti-alveolar hydatid and antihymenolepiasis activity of 1-alkyl-4[4-(heterylamino)phenyl]piperazines]. Med Parazitol (Mosk). 1991 Sep-Oct;( PMID:1758368 |
|
| Company Name: |
PHARMEKS Ltd.
|
| Tel: |
+7 (495) 702-9648 |
| Website: |
www.pharmeks.com |
|