| Identification | Back Directory | [Name]
Ro 23-9424 | [CAS]
115622-58-7 | [Synonyms]
Ro 23-9424
5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2Z)-(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-[[[[6,8-difluoro-1-(2-fluoroethyl)-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinyl]carbonyl]oxy]methyl]-8-oxo-, (6R,7R)- (9CI) | [Molecular Formula]
C31H31F3N8O8S2 | [MDL Number]
MFCD00877052 | [MOL File]
115622-58-7.mol | [Molecular Weight]
764.75 |
| Hazard Information | Back Directory | [Uses]
Ro 23-9424 is a broad-spectrum cephalosporin composed of a cephalosporin and a quinolone moiety. Ro 23-9424 shows antimicrobial activity in vivo and in vitro[1][2][3]. | [IC 50]
Quinolone | [References]
[1] Pfaller MA, et al. RO 23-9424, a new cephalosporin 3'-quinolone: in-vitro antimicrobial activity and tentative disc diffusion interpretive criteria. J Antimicrob Chemother. 1993;31(1):81-88. DOI:10.1093/jac/31.1.81
[2] Christenson JG, et al. Pharmacokinetics of Ro 23-9424, a dual-action cephalosporin, in animals. Antimicrob Agents Chemother. 1990;34(10):1895-1900. DOI:10.1128/AAC.34.10.1895
[3] Matera G, et al. Effect of RO 23-9424, cefotaxime and fleroxacin on functions of human polymorphonuclear cells and cytokine production by human monocytes. J Antimicrob Chemother. 1996;38(5):799-807. DOI:10.1093/jac/38.5.799 |
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