| Identification | Back Directory | [Name]
Cardiotoxin Analog (CTX) IV 6-12 | [CAS]
115722-23-1 | [Synonyms]
L-Lysinamide, L-leucyl-L-isoleucyl-L-prolyl-L-prolyl-L-phenylalanyl-L-tryptophyl- (9CI) | [Molecular Formula]
C48H70N10O7 | [MOL File]
115722-23-1.mol | [Molecular Weight]
899.13 |
| Chemical Properties | Back Directory | [Boiling point ]
1240.9±65.0 °C(Predicted) | [density ]
1.236±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
13.45±0.20(Predicted) | [color ]
White to off-white | [Sequence]
H-Leu-Ile-Pro-Pro-Phe-Trp-Lys-NH2 |
| Hazard Information | Back Directory | [Uses]
Cardiotoxin Analog (CTX) IV (6-12) is a membrane active peptide that specifically targets negatively charged phospholipid membranes (such as phosphatidylserine and phosphatidylinositol). Cardiotoxin Analog (CTX) IV (6-12) binds to cell membranes through hydrophobic interactions and electrostatic attraction. Cardiotoxin Analog (CTX) IV (6-12) is mainly embedded in the lipid bilayer through the N-terminal hydrophobic loop (amino acid sequence at positions 6-12), destroying the stability of the membrane structure, inducing membrane lipid disorder and cell lysis, and exhibiting hemolysis and cytotoxicity[1][2]. | [References]
[1] Kaneda N, et al. The amino acid sequence of cardiotoxin-analogue IV from the venom of Naja naja atra. FEBS Lett. 1976 Nov;70(1):217-22. DOI:10.1016/0014-5793(76)80761-2
[2] Dufourcq J, et al. Structure-function relationships for cardiotoxins interacting with phospholipids. Toxicon. 1982;20(1):165-74. DOI:10.1016/0041-0101(82)90187-8 |
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