| Identification | Back Directory | [Name]
Benzenemethanamine, 3-chloro-4-[(4-chlorophenyl)methoxy]-N-cyclopentyl-5-ethoxy-, hydrochloride (1:1) | [CAS]
1158607-44-3 | [Synonyms]
Benzenemethanamine, 3-chloro-4-[(4-chlorophenyl)methoxy]-N-cyclopentyl-5-ethoxy-, hydrochloride (1:1) | [Molecular Formula]
C21H26Cl3NO2 | [MDL Number]
MFCD07105783 | [MOL File]
1158607-44-3.mol | [Molecular Weight]
430.79 |
| Hazard Information | Back Directory | [Description]
ML358 is a selective inhibitor of SKN-1 pathway involved in drug detoxification and resistance in nematodes. | [Uses]
ML358 is a first in class, potent, and selective inhibitor of the SKN-1 pathway (IC50=0.24 μM). ML358 sensitizes the model nematode C. elegans to oxidants and anthelmintic. ML358 potentially used as adjuvants to increase the efficacy and useful life of current anthelmintics[1]. | [References]
[1] Peddibhotla, S, et al.?Discovery of ML358, a Selective Small Molecule Inhibitor of the SKN-1 Pathway Involved in Drug Detoxification and Resistance in Nematodes. ACS Chemical Biology, 10(8), 1871–1879. DOI:10.1021/acschembio.5b00304 |
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