| Identification | Back Directory | [Name]
CL 275838 | [CAS]
115931-65-2 | [Synonyms]
CL 275838
Pyrazolo[1,5-a]pyrimidine-3-carbonitrile, 4,5-dihydro-4-[2-[4-(phenylmethyl)-1-piperazinyl]acetyl]-7-[3-(trifluoromethyl)phenyl]- | [Molecular Formula]
C27H25F3N6O | [MDL Number]
MFCD00869627 | [MOL File]
115931-65-2.mol | [Molecular Weight]
506.52 |
| Chemical Properties | Back Directory | [Boiling point ]
636.7±55.0 °C(Predicted) | [density ]
1.33±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [pka]
6.62±0.10(Predicted) |
| Hazard Information | Back Directory | [Uses]
CL-275838 is a memory-enhancing agent, also with potent antidepressant activities. | [in vivo]
CL 275,838 metabolism has sex-dependent differences in rat. CL 275,838 does not appreciably affect its own oxidation or cause significant hepatic microsomal enzyme induction in the male or female rat, except for slight enhancement of some components of the P450 system at doses (300?mg/kg once daily for 7 days) well above the effective pharmacological range[1]. | [storage]
Store at -20°C | [References]
[1] Ferrarese A, et al. Hepatic microsomal metabolism of the potential memory-enhancing agent, CL 275,838, to its desbenzyl derivative. Xenobiotica. 1993 Sep;23(9):1007-16. DOI:10.3109/00498259309057039 |
|
|