| Identification | Back Directory | [Name]
PDE4 (R)-(-)-RolipraM | [CAS]
1160521-50-5 | [Synonyms]
PDE1-IN-1
ITI214 (free base)
PDE4 (R)-(-)-RolipraM
(6aR,9aS)-2-(4-(6-fluoropyridin-2-yl)benzyl)-5-methyl-3-(phenylamino)-5,6a,7,8,9,9a-hexahydrocyclopenta[4,5]imidazo[1,2-a]pyrazolo[4,3-e]pyrimidin-4(2H)-one
Cyclopent[4,5]imidazo[1,2-a]pyrazolo[4,3-e]pyrimidin-4(2H)-one, 2-[[4-(6-fluoro-2-pyridinyl)phenyl]methyl]-5,6a,7,8,9,9a-hexahydro-5-methyl-3-(phenylamino)-, (6aR,9aS)- | [Molecular Formula]
C29H26FN7O | [MDL Number]
MFCD28385866 | [MOL File]
1160521-50-5.mol | [Molecular Weight]
507.56 |
| Chemical Properties | Back Directory | [Boiling point ]
731.7±70.0 °C(Predicted) | [density ]
1.45±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
2.06±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
ITI-214 free base is a potent, CNS-active, orally bioavailable PDE1 inhibitor (Ki of 58 pM) with excellent selectivity against other PDE family members and against a panel of enzymes, receptors, transporters and ion channels. ITI-214 free base inhibits recombinant full-length human PDE1A, PDE1B and PDE1C with Kis of 33 pM, 380 pM and 35 pM, respectively. ITI-214 free base shows efficacy in various animal models of motor and cognitive functions[1][2]. | [in vivo]
ITI-214 significantly enhances memory performance in the test with a minimum effective dose of 3 mg/kg[1]. | Animal Model: | Male Sprague-Dawley rats[1] | | Dosage: | 0.1-10 mg/kg | | Administration: | P.o. | | Result: | Significantly enhanced memory performance in the test with a minimum effective dose of 3 mg/kg.
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| [IC 50]
PDE1: 58 pM (Ki); PDE1A: 33 pM (Ki); PDE1B: 380 pM (Ki); PDE1C: 35 pM (Ki) | [References]
[1] Li P, et al. Discovery of Potent and Selective Inhibitors of Phosphodiesterase 1 for the Treatment of Cognitive Impairment Associated with Neurodegenerative and Neuropsychiatric Diseases. J Med Chem. 2016 Feb 11;59(3):1149-64. DOI:10.1021/acs.jmedchem.5b01751
[2] Lawrence Wennogle. Novel uses. From PCT Int. Appl. (2014), WO 2014145617 A2 20140918.
[3] Peng Li , et al. Salt crystals. From PCT Int. Appl. (2013), WO 2013192556 A2 20131227.
[4] Allen A. Fienberg, et al. Organic compounds. From PCT Int. Appl. (2010), WO 2010132127 A1 20101118. |
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| Company Name: |
BOC Sciences
|
| Tel: |
16314854226 |
| Website: |
www.bocsci.com |
| Company Name: |
Musechem
|
| Tel: |
+1-800-259-7612 |
| Website: |
www.musechem.com |
|