ChemicalBook--->CAS DataBase List--->1161233-85-7

1161233-85-7

1161233-85-7 Structure

1161233-85-7 Structure
IdentificationBack Directory
[Name]

BTZ043
[CAS]

1161233-85-7
[Synonyms]

BTZ043
CS-2310
PBTZ 169
BTZ 10526043
BTZ043 raceMate
BTZ043 (BTZ-043
BTZ043;BTZ-043;BTZ 043
2-[(3S)-3-methyl-1,4-dioxa-8-azaspiro[4.5]decan-8-yl]-8-nitro-6-(trifluoromethyl)-1,3-benzothiazin-4-one
2-[(2S)-2-Methyl-1,4-dioxa-8-azaspiro[4.5]decan-8-yl]-8-nitro-6-trifluoromethyl-4H-1,3-benzothiazin-4-one
4H-1,3-Benzothiazin-4-one, 2-[(2S)-2-methyl-1,4-dioxa-8-azaspiro[4.5]dec-8-yl]-8-nitro-6-(trifluoromethyl)-
[Molecular Formula]

C17H16F3N3O5S
[MDL Number]

MFCD17215196
[MOL File]

1161233-85-7.mol
[Molecular Weight]

431.39
Chemical PropertiesBack Directory
[Melting point ]

190-191°C
[density ]

1.68
[storage temp. ]

-20°C Freezer
[solubility ]

Chloroform (Slightly), Methanol (Very Slightly)
[form ]

Solid
[color ]

White to Pale Yellow
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P305+P351+P338
Hazard InformationBack Directory
[Uses]

BTZ043 is an inhibitor of the essential flavo-enzyme Decaprenylphosphoryl-beta-D-ribose 2-epimerase (DprE1).
[in vivo]

Four weeks of treatment with BTZ043 reduces the bacterial burden in the lungs and spleens by 1 and 2 logs, respectively, at the concentrations used. Additional results suggest that BTZ043 efficacy is time-rather than dose-dependent. Acute (5 g/kg) and chronic (25 and 250 mg/kg) toxicology studies in uninfected mice show that, even at the highest dose tested, there are no adverse anatomical, behavioral, or physiological effects after one month[2].

[storage]

Store at -20°C
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