| Identification | Back Directory | [Name]
Imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide, 3-(2-fluoroethyl)-3,4-dihydro-4-oxo- | [CAS]
1161826-19-2 | [Synonyms]
Imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide, 3-(2-fluoroethyl)-3,4-dihydro-4-oxo- | [Molecular Formula]
C7H7FN6O2 | [MOL File]
1161826-19-2.mol | [Molecular Weight]
226.17 |
| Chemical Properties | Back Directory | [Boiling point ]
538.8±56.0 °C(Predicted) | [density ]
1.91±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
14.95±0.20(Predicted) | [color ]
Off-white to pink |
| Hazard Information | Back Directory | [Uses]
KL-50 is a selective toxin toward tumors that lack the DNA repair protein O6-methylguanine-DNA-methyltransferase (MGMT), which reverses the formation of O6-alkylguanine lesions. KL-50 activates DNA damage response pathways and cycle arrest in MGMT-cells, independent of mismatch repair (MMR). KL-50 is promising for research of brain tumors that lack the DNA repair protein MGMT[1][2]. | [References]
[1] Huseman ED, et al. Mechanism of Action of KL-50, a Candidate Imidazotetrazine for the Treatment of Drug-Resistant Brain Cancers. J Am Chem Soc. 2024 Jul 10;146(27):18241-18252. DOI:10.1021/jacs.3c06483
[2] HERZON Seth, et al. Preparation of imidazotetrazine compounds and methods for treating cancers that are MGMT deficient regardless of MMR status. WO2023049806. 2022 September 22. |
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