| Identification | Back Directory | [Name]
Propargyl-PEG5-CH2CO2-NHS | [CAS]
1161883-51-7 | [Synonyms]
Propargyl-PEG4-CH2COONHS
Propargyl-PEG5-CH2CO2-NHS
Propargyl-PEG4-O-C1-NHS ester
Propargyl-PEG5-CH2COO-NHS ester
3,6,9,12,15-Pentaoxaoctadec-17-ynoic acid, 2,5-dioxo-1-pyrrolidinyl ester | [Molecular Formula]
C17H25NO9 | [MDL Number]
MFCD31561142 | [MOL File]
1161883-51-7.mol | [Molecular Weight]
387.38 |
| Hazard Information | Back Directory | [Description]
Propargyl-PEG5-CH2CO2-NHS is an amine reactive linker with an alkyne moeity which can react with azide-bearing biomolecules in copper catalyzed Click Chemistry reactions. The PEG units enhance the solubility of the linker in aqueous media. | [Uses]
Propargyl-PEG4-O-C1-NHS ester (compound 8) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG4-O-C1-NHS ester is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] Kussrow A, et al. Measurement of monovalent and polyvalent carbohydrate-lectin binding by back-scatteringinterferometry. Anal Chem. 2009 Jun 15;81(12):4889-97. DOI:10.1021/ac900569c |
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