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1162264-07-4

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1162264-07-4 Structure

1162264-07-4 Structure
IdentificationBack Directory
[Name]

LY2623091
[CAS]

1162264-07-4
[Synonyms]

LY2623091
LY2623091 (LY-2623091
Urea, N-[5-[(E)-(3-fluorodibenz[b,e]oxepin-11(6H)-ylidene)methyl]-1,3-dihydro-1-[(1R)-1-methyl-2-(4-morpholinyl)ethyl]-2H-benzimidazol-2-ylidene]-, [N(E)]-
[Molecular Formula]

C30H30FN5O3
[MDL Number]

MFCD26406001
[MOL File]

1162264-07-4.mol
[Molecular Weight]

527.6
Chemical PropertiesBack Directory
[density ]

1.37±0.1 g/cm3(Predicted)
[pka]

13.75±0.30(Predicted)
Hazard InformationBack Directory
[Uses]

LY2623091 is a mineralocorticoid receptor antagonist for the treatment of refractory hypertension. LY2623091 exhibits CYP3A4-dependent clearance and synergistic effects with CYP3A4 inhibitors[1][2].
[References]

[1] Dickinson G L, et al. Physiologically based pharmacokinetic modeling to understand the observed drug–drug interaction of LY2623091 with CYP3A inhibitors itraconazole and diltiazem[J]. International journal of Pharmacokinetics, 2017, 2(4): 233-245.
[2] Kocienski P. Synthesis of LY2623091[J]. Synfacts, 2017, 13(05): 0451.
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