| Identification | Back Directory | [Name]
Watanipidine monohydrochloride | [CAS]
116308-56-6 | [Synonyms]
AE0047 Hydrochloride
Watanipidine monohydrochloride | [Molecular Formula]
C41H43ClN4O6 | [MDL Number]
MFCD01938787 | [MOL File]
116308-56-6.mol | [Molecular Weight]
723.256 |
| Hazard Information | Back Directory | [Uses]
AE0047 Hydrochloride is a calcium blocker, used in the research of hypertensive disease. | [in vivo]
AE0047 (3 mg/kg) shows antihypertensive effect, and reduces systolic blood pressure with ED30 of 1.1 mg/kg[2]. AE0047 (1 or 3 mg/25g SP diet) inhibits blood pressure elevation and improves endothelium-dependent relaxation in response to acetylcholine in aorta isolated from stroke-prone spontaneously hypertensive rats (SHRSP)[4]. | [storage]
Store at -20°C | [References]
[1] Ashimori A, et al. Novel 1,4-dihydropyridine calcium antagonists. II. Synthesis and antihypertensive activity of 3-[4-(substituted amino)phenylalkyl]ester derivatives. Chem Pharm Bull (Tokyo). 1991 Jan;39(1):91-9. DOI:10.1248/cpb.39.91
[2] Ashimori A, et al. Synthesis and pharmacological effects of optically active 2-[4-(4-benzhydryl-1-piperazinyl)phenyl]-ethyl methyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate hydrochloride. Chem Pharm Bull (Tokyo). 1991 Jan;39(1):108-11. DOI:10.1248/cpb.39.108
[3] Yamanaga K, et al. AE0047-mediated calcium channel blocking in vascular smooth muscles. Gen Pharmacol. 1997 Sep;29(3):337-43. DOI:10.1016/s0306-3623(96)00515-0
[4] Nishikawa M, et al. Protection against endothelial abnormalities by a novel calcium channel blocker, AE0047, in stroke-prone spontaneously hypertensive rats. Gen Pharmacol. 1999 Mar;32(3):299-305. DOI:10.1016/s0306-3623(98)00180-3 |
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