| Identification | Back Directory | [Name]
4-Bromo-5-chloro-2-fluoroaniline | [CAS]
116369-24-5 | [Synonyms]
4-Bromo-5-chloro-2-fluoroaniline
Benzenamine, 4-bromo-5-chloro-2-fluoro- | [Molecular Formula]
C6H4BrClFN | [MDL Number]
MFCD09878173 | [MOL File]
116369-24-5.mol | [Molecular Weight]
224.46 |
| Chemical Properties | Back Directory | [Boiling point ]
258.9±35.0 °C(Predicted) | [density ]
1.809±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,2-8°C | [pka]
1.44±0.10(Predicted) | [Appearance]
Off-white to gray Solid |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of 4-bromo-5-chloro-2-fluoroaniline from 2-fluoro-5-chloroaniline: N-bromosuccinimide (1 eq.) was added to a solution of 5-chloro-2-fluoroaniline (1 eq.) in acetonitrile (0.5 M) at 25 °C. The reaction mixture was stirred at 25 °C for 1 hour. After completion of the reaction, the mixture was concentrated to dryness and the residue obtained was purified by silica gel column chromatography to afford 4-bromo-5-chloro-2-fluoroaniline in 91% yield as a yellow oil.1H NMR (400 MHz, CDCl3) δppm: 7.23 (d, J = 10.2 Hz, 1H), 6.88 (d, J = 8.4 Hz, 1H), 3.92- 2.64 (br, 2H). | [References]
[1] Patent: US2016/96841, 2016, A1. Location in patent: Paragraph 0370 |
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| Company Name: |
J & K SCIENTIFIC LTD.
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| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Cool Pharm, Ltd
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| Telephone: |
021-60455363 18019463053 |
| Website: |
www.coolpharm.com |
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