| Identification | Back Directory | [Name]
2'-Deoxy-2',2'-difluoro-5'-cytidylic Acid | [CAS]
116371-67-6 | [Synonyms]
Gemcitabine Monophosphate
Gemcitibine monophosphate formate salt
Gemcitabine Monophosphate Formate Salt
2'-Deoxy-2',2'-difluoro-5'-cytidylic Acid
5'-Cytidylic acid, 2'-deoxy-2',2'-difluoro-
2'-Deoxy-2',2'-difluoro-5'-cytidylic Acid ForMate
2',2'-Difluoro-2'-deoxycytidine 5'-phosphoric acid
2',2'-Difluoro-2'-deoxycytidine-5'-phosphoric acid
GeMcitabine Monophosphate disodiuM salt Monohydrate
2'-Deoxy-2',2'-difluorocytidine monophosphate formate salt
2'-Deoxy-2',2'-difluorocytidine 5'-monophosphate formate salt
((2R,3R,5R)-5-(4-Amino-2-oxopyrimidin-1(2H)-yl)-4,4-difluoro-3-hydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate | [Molecular Formula]
C9H12F2N3O7P2.5 | [MDL Number]
MFCD18252926 | [MOL File]
116371-67-6.mol | [Molecular Weight]
343.18 |
| Chemical Properties | Back Directory | [Melting point ]
151-153?C | [Boiling point ]
618.3±65.0 °C(Predicted) | [density ]
2.09 | [storage temp. ]
Hygroscopic, -20°C Freezer, Under Inert Atmosphere | [solubility ]
DMSO (Slightly), Water (Slightly) | [form ]
Solid | [pka]
1.86±0.10(Predicted) | [color ]
White to Off-White | [Stability:]
Hygroscopic |
| Hazard Information | Back Directory | [Chemical Properties]
White to Off-White Solid | [Uses]
Gemcitabine derivative. An antineoplastic agent | [Uses]
Gemcitabine Monophosphate is a gemcitabine derivative. It is an antineoplastic agent. | [in vivo]
Gemcitabine monophosphate (19.5 mg/kg, intravenous injection, every other day, four injections) combined with LCP loaded with VEGF siRNA and GMP shows anti-small cell lung cancer activity and induces apoptosis[1]. | Animal Model: | Subcutaneous and orthotopic xenograft mouse models of non-small cell lung cancer[1] | | Dosage: | 19.5 mg/kg, every other day, four injections | | Administration: | Intravenous injection (i.v.) | | Result: | Induced tumor cell apoptosis to 30-40%, reduced tumor cell proliferation by 8 times, significantly reduced tumor microvessel density (MVD), and inhibited tumor mitosis. |
| [storage]
Store at -20°C |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Finetech Industry Limited
|
| Telephone: |
+86-27-8746-5837 +86-18627785180 |
| Website: |
https://www.finetechnology-ind.com/ |
| Company Name: |
NewCan Biotech Limited
|
| Telephone: |
+86-571-86912261 19975279805 |
| Website: |
https://www.newcanbio.com/ |
|