| Identification | Back Directory | [Name]
CHOLIC-2,2,4,4-D4 ACID | [CAS]
116380-66-6 | [Synonyms]
Cholic-d4 Acid
Cholic acid-2,2,4,4-d
Cholic Acid -[d4] (Solution)
Cholic Acid-d4 MaxSpec? Standard
5β-cholanic acid-3α,7α,12α-triol-2,2,4,4-d4
CHOLIC ACID (2,2,4,4-D4, 98%) 100 UG/ML IN METHANOL | [Molecular Formula]
C24H36D4O5 | [MDL Number]
MFCD00190405 | [MOL File]
116380-66-6.mol | [Molecular Weight]
412.6 |
| Chemical Properties | Back Directory | [Melting point ]
200-201°C (lit.) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 30 mg/ml,DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml,DMSO: 20 mg/ml,Ethanol: 20 mg/ml | [form ]
Solid | [color ]
White to Off-White | [InChIKey]
BHQCQFFYRZLCQQ-XJNZYMKVNA-N | [CAS Number Unlabeled]
81-25-4 |
| Hazard Information | Back Directory | [Description]
Cholic acid-d4 is intended for use as an internal standard for the quantification of cholic acid (Item No. 20250) by GC- or LC-MS. Cholic acid is a primary bile acid.1 It is formed from cholesterol via a multistep process catalyzed by the cytochrome P450 (CYP) isoforms CYP7A1, CYP8B1, and CYP27A1. Cholic acid is conjugated to glycine or taurine by bile acid-CoA:amino acid N-acyltransferase (BAAT) to produce glycocholic acid (GCA; Item No. 20276) and taurocholic acid (TCA; Item No. 16215), respectively, in the liver, and is transformed into the secondary bile acid deoxycholic acid (DCA; Item No. 20756) by intestinal microbiota.1,2,3 It induces C. difficile colony formation in an agar dilution assay when used at a concentration of 0.1% w/v.4 Dietary administration of cholic acid (0.4% w/w) increases serum cholesterol levels, biliary phospholipid secretion, and fecal DCA levels in rats.5 | [Uses]
Cholic Acid-d4 is a labelled analog of Cholic acid (C432600) which is a choleretic produced by, and isolated from liver cells. | [Definition]
ChEBI:Cholic acid-2,2,4,4-d4 is a bile acid. | [storage]
Store at -20°C | [References]
[1] TANJA M ?ARENAC Momir M. Bile Acid Synthesis: From Nature to the Chemical Modification and Synthesis and Their Applications as Drugs and Nutrients.[J]. Frontiers in Pharmacology, 2018: 939. DOI: 10.3389/fphar.2018.00939
[2] MARY C. HUNT Stefan E H A Marina I Siponen. The emerging role of acyl-CoA thioesterases and acyltransferases in regulating peroxisomal lipid metabolism[J]. Biochimica et biophysica acta. Molecular basis of disease, 2012, 1822 9: Pages 1397-1410. DOI: 10.1016/j.bbadis.2012.03.009
[3] CHRISTOPHER STALEY. Interaction of gut microbiota with bile acid metabolism and its influence on disease states[J]. Applied Microbiology and Biotechnology, 2016, 101 1: 47-64. DOI: 10.1007/s00253-016-8006-6
[4] JOSEPH A SORG A L S. Bile salts and glycine as cogerminants for Clostridium difficile spores.[J]. Journal of Bacteriology, 2008: 2505-2512. DOI: 10.1128/jb.01765-07
[5] K UCHIDA N T Y Nomura. Effects of cholic acid, chenodeoxycholic acid, and their related bile acids on cholesterol, phospholipid, and bile acid levels in serum, liver, bile, and feces of rats.[J]. Journal of biochemistry, 1980, 87 1: 187-194. DOI: 10.1093/oxfordjournals.jbchem.a132724
[6] PENGXIANG QU. DT-109 ameliorates nonalcoholic steatohepatitis in nonhuman primates.[J]. Cell metabolism, 2023, 35 5: 742-757.e10. DOI: 10.1016/j.cmet.2023.03.013 |
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