| Identification | Back Directory | [Name]
3-[4-[[[(3-Methylphenyl)amino]carbonyl]amino]-1H-pyrazol-1-yl]-N-(3,4,5-trimethoxyphenyl)-benzamide | [CAS]
1164153-22-3 | [Synonyms]
SR-3576
JNK3 Inhibitor XII
SR-3576 >=98% (HPLC)
JNK3 Inhibitor XII, SR-3576
JNK3 Inhibitor XII, SR-3576 - CAS 1164153-22-3 - Calbiochem
3-(5-(3-m-Tolylureido)-1H-indazol-1-yl)-N-(3,4,5-trimethoxyphenyl)benzamide
3-[4-(3-m-Tolyl-ureido)-pyrazol-1-yl]-N-(3,4,5-trimethoxy-phenyl)-benzamide
3-[4-[[[(3-Methylphenyl)amino]carbonyl]amino]-1H-pyrazol-1-yl]-N-(3,4,5-trimethoxyphenyl)-benzamide | [Molecular Formula]
C27H27N5O5 | [MDL Number]
MFCD18632556 | [MOL File]
1164153-22-3.mol | [Molecular Weight]
501.53 |
| Chemical Properties | Back Directory | [Boiling point ]
557.7±50.0 °C(Predicted) | [density ]
1.27±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: ≥20mg/mL | [form ]
powder | [pka]
11.51±0.70(Predicted) | [color ]
light brown to brown | [Stability:]
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month. |
| Hazard Information | Back Directory | [Description]
SR-3576 (1164153-22-3) is a potent and selective JNK3 inhibitor. IC50?= 7nM and >2800-fold selective over p38.1?Cell permeable. | [Uses]
SR 3576 is a JNK-3 selective inhibitor. | [General Description]
A cell-permeable pyrazolourea compound that acts as a potent, ATP binding pocket-targeting, and JNK3-selective inhibitor (IC50 = 7 nM), inhibiting JNK1 only at much higher concentrations (IC50 = 170 nM) and exhibiting little activity against p38 even at concentrations as high as 20 μM. Shown to inhibit streptozotocin- (Cat. No. 572201) induced c-jun phosphorylation in INS-1 rat β-pancreatic cells (IC50 = 1.3 μM). | [Biochem/physiol Actions]
SR-3576 is a small molecule inhibitor belonging to aminopyrazole class that selectively inhibits JNK3 with >2800 fold selectively over p38.1 | [storage]
Store at -20°C | [References]
1) Kamenecka?et al. (2009),?Structure-activity relationships and X-ray structures describing the selectivity of aminopyrazole inhibitors for c-Jun N-terminal kinase 3 (JNK3) over p38; J. Biol. Chem.,?284?12853 |
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Energy Chemical
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Merck Millipore
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