| Identification | Back Directory | [Name]
1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-naphthalen-1-yloxypropan-2-ol:hydrochloride | [CAS]
1164469-60-6 | [Synonyms]
1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-naphthalen-1-yloxypropan-2-ol:hydrochloride | [Molecular Formula]
C24H29ClN2O3 | [MOL File]
1164469-60-6.mol | [Molecular Weight]
428.952 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 10 mg/mL; DMF:PBS (pH 7.2) (1:4): 0.2 mg/mL; DMSO: 3 mg/mL | [form ]
A crystalline solid |
| Hazard Information | Back Directory | [Uses]
Naftopidil Hydrochloride is an α-1-adrenergic receptor antagonist. Naftopidil is used as an antihypertensive. | [in vivo]
Naftopidil hydrochloride (10 mg/kg; p.o; daily; for 28 days) decreases microvessel density (MVD) in E9+PrSC tumors mice model[2].
| Animal Model: | Male athymic mice(7-8 weeks), with E9+PrSC xenograft[2] | | Dosage: | 10 mg/kg | | Administration: | Oral administration, daily, for 28 days | | Result: | Decreased tumor weights. |
| [IC 50]
Alpha-1A adrenergic receptor: 3.7 nM (Ki); Alpha-1B adrenergic receptor: 20 nM (Ki); Alpha-1D adrenergic receptor: 1.2 nM (Ki) | [storage]
Store at RT |
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