| Identification | Back Directory | [Name]
3' 4'-DICHLOROBENZAMIL | [CAS]
1166-01-4 | [Synonyms]
Dichlorobenzamil
3' 4'-DICHLOROBENZAMIL
4'-Dichlorobenzamil HCl
3',4'-Dichlorobenzamil HCl
3',4' Dichlorobenzamil HCl,3',4'Dichlorobenzamil HCl
3,5-diamino-6-chloro-N-[N'-(3,4-dichlorobenzyl)carbamimidoyl]pyrazinamide
3,5-diamino-6-chloro-N-[N'-[(3,4-dichlorophenyl)methyl]carbamimidoyl]pyrazine-2-carboxamide
N-[Imino[(3,4-dichlorophenylmethyl)amino]methyl]-3,5-diamino-6-chloro-2-pyrazinecarboxamide
3,5-Diamino-6-chloro-N-[[(3,4-dichlorophenyl)methylamino](imino)methyl]-2-pyrazinecarboxamide
3,5-bis(azanyl)-6-chloro-N-[N'-[(3,4-dichlorophenyl)methyl]carbamimidoyl]pyrazine-2-carboxamide | [Molecular Formula]
C13Cl3H12N7O1 | [MDL Number]
MFCD03425383 | [MOL File]
1166-01-4.mol | [Molecular Weight]
425.1 |
| Hazard Information | Back Directory | [Uses]
Dichlorobenzamil (3',4'-Dichlorobenzamil; L-594881) is an effective Na/Ca exchange inhibitor. Dichlorobenzamil significantly inhibits 45Ca uptake mediated by reverse Na/Ca exchange in pancreatic islet cells (IC50 = 18 μM). Dichlorobenzamil can also block K+ channels and voltage-sensitive Ca2+ channels[1]. | [Definition]
ChEBI: 3,5-diamino-N-[amino-[(3,4-dichlorophenyl)methylimino]methyl]-6-chloro-2-pyrazinecarboxamide is a member of pyrazines and a member of guanidines. | [References]
[1] Plasman P O, et al. Inhibition of Na/Ca exchange in pancreatic islet cells by 3′, 4′-dichlorobenzamil[J]. Biochemical pharmacology, 1991, 41(11): 1759-1768. DOI:10.1016/0006-2952(91)90181-4 |
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