| Identification | Back Directory | [Name]
Mtx-ala | [CAS]
116819-28-4 | [Synonyms]
Mtx-ala
methotrexate-alpha-alanine
Methotrexate alpha alanine,Methotrexatealphaalanine
L-Alanine, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-α-glutamyl- | [Molecular Formula]
C23H27N9O6 | [MOL File]
116819-28-4.mol | [Molecular Weight]
525.52 |
| Hazard Information | Back Directory | [Uses]
Methotrexate-alpha-alanine is a prodrug for activation by enzyme-monoclonal antibody conjugates. Methotrexate-alpha-alanine shows cytotoxicity[1][2]. | [References]
[1] Haenseler E, et al. Activation of methotrexate-alpha-alanine by carboxypeptidase A-monoclonal antibody conjugate. Biochemistry. 1992 Jan 28;31(3):891-7. DOI:10.1021/bi00118a035
[2] Huennekens FM. Development of methotrexate alpha-peptides as prodrugs for activation by enzyme-monoclonal antibody conjugates. Adv Enzyme Regul. 1997;37:77-92. DOI:10.1016/s0065-2571(96)00011-8 |
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